Literature DB >> 17291816

Quantitative PCR-based screening of alpha-synuclein multiplication in multiple system atrophy.

Sarah J Lincoln1, Owen A Ross, Nicole M Milkovic, Dennis W Dickson, Alex Rajput, Christopher A Robinson, Spiridon Papapetropoulos, Deborah C Mash, Matthew J Farrer.   

Abstract

Multiple system atrophy (MSA) is by nature a 'sporadic' disease with no evidence of familial aggregation observed. However, the alpha-synuclein locus (SNCA) multiplication families have clinically displayed parkinsonism and autonomic dysfunction. The present study did not find any SNCA multiplications in a series of 58 pathologically confirmed MSA cases excluding this event as a common cause of MSA. The question of a genetic component in MSA remains to be answered.

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Year:  2007        PMID： 17291816      PMCID： PMC2269731          DOI： 10.1016/j.parkreldis.2006.12.005

Source DB:  PubMed          Journal:  Parkinsonism Relat Disord        ISSN： 1353-8020            Impact factor:   4.891


  22 in total

1.  Analysis of the expression level of alpha-synuclein mRNA using postmortem brain samples from pathologically confirmed cases of multiple system atrophy.

Authors:  T Ozawa; K Okuizumi; T Ikeuchi; K Wakabayashi; H Takahashi; S Tsuji
Journal:  Acta Neuropathol       Date:  2001-08       Impact factor: 17.088

Review 2.  The definition of multiple system atrophy: a review of recent developments.

Authors:  P L Lantos
Journal:  J Neuropathol Exp Neurol       Date:  1998-12       Impact factor: 3.685

3.  Alpha-synuclein in Lewy bodies.

Authors:  M G Spillantini; M L Schmidt; V M Lee; J Q Trojanowski; R Jakes; M Goedert
Journal:  Nature       Date:  1997-08-28       Impact factor: 49.962

4.  Multiple system atrophy/progressive supranuclear palsy: alpha-Synuclein, synphilin, tau, and APOE.

Authors:  H R Morris; J R Vaughan; S R Datta; R Bandopadhyay; H A Rohan De Silva; A Schrag; N J Cairns; D Burn; U Nath; P L Lantos; S Daniel; A J Lees; N P Quinn; N W Wood
Journal:  Neurology       Date:  2000-12-26       Impact factor: 9.910

5.  Multiple-system atrophy is genetically distinct from identified inherited causes of spinocerebellar degeneration.

Authors:  O Bandmann; M G Sweeney; S E Daniel; G K Wenning; N Quinn; C D Marsden; N W Wood
Journal:  Neurology       Date:  1997-12       Impact factor: 9.910

6.  Glial cytoplasmic inclusions in the CNS of patients with multiple system atrophy (striatonigral degeneration, olivopontocerebellar atrophy and Shy-Drager syndrome).

Authors:  M I Papp; J E Kahn; P L Lantos
Journal:  J Neurol Sci       Date:  1989-12       Impact factor: 3.181

7.  A novel cytochrome P-450IID6 (CYPIID6) mutant gene associated with multiple system atrophy.

Authors:  K Iwahashi; R Miyatake; Y Tsuneoka; Y Matsuo; Y Ichikawa; K Hosokawa; K Sato; T Hayabara
Journal:  J Neurol Neurosurg Psychiatry       Date:  1995-02       Impact factor: 10.154

8.  Comparison of kindreds with parkinsonism and alpha-synuclein genomic multiplications.

Authors:  Matt Farrer; Jennifer Kachergus; Lysia Forno; Sarah Lincoln; Deng-Shun Wang; Mary Hulihan; Demetrius Maraganore; Katrina Gwinn-Hardy; Zbigniew Wszolek; Dennis Dickson; J William Langston
Journal:  Ann Neurol       Date:  2004-02       Impact factor: 10.422

9.  Arg296 to Cys296 polymorphism in exon 6 of cytochrome P-450-2D6 (CYP2D6) is not associated with multiple system atrophy.

Authors:  O Bandmann; G K Wenning; N P Quinn; A E Harding
Journal:  J Neurol Neurosurg Psychiatry       Date:  1995-11       Impact factor: 10.154

Review 10.  Multiple system atrophy.

Authors:  Gregor K Wenning; Carlo Colosimo; Felix Geser; Werner Poewe
Journal:  Lancet Neurol       Date:  2004-02       Impact factor: 44.182
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  14 in total

1.  Reply to: SNCA variants are associated with increased risk of multiple system atrophy.

Authors:  Owen A Ross; Carles Vilariño-Güell; Zbigniew K Wszolek; Matthew J Farrer; Dennis W Dickson
Journal:  Ann Neurol       Date:  2010-03       Impact factor: 10.422

Review 2.  Review: Novel treatment strategies targeting alpha-synuclein in multiple system atrophy as a model of synucleinopathy.

Authors:  E Valera; G Monzio Compagnoni; E Masliah
Journal:  Neuropathol Appl Neurobiol       Date:  2016-02       Impact factor: 8.090

3.  Genetic players in multiple system atrophy: unfolding the nature of the beast.

Authors:  Sylvia Stemberger; Sonja W Scholz; Andrew B Singleton; Gregor K Wenning
Journal:  Neurobiol Aging       Date:  2011-05-24       Impact factor: 4.673

Review 4.  Recent developments in multiple system atrophy.

Authors:  Gregor K Wenning; Nadia Stefanova
Journal:  J Neurol       Date:  2009-05-27       Impact factor: 4.849

Review 5.  Multiple system atrophy: experimental models and reality.

Authors:  Cassia Overk; Edward Rockenstein; Elvira Valera; Nadia Stefanova; Gregor Wenning; Eliezer Masliah
Journal:  Acta Neuropathol       Date:  2017-10-20       Impact factor: 17.088

Review 6.  Genetics Underlying Atypical Parkinsonism and Related Neurodegenerative Disorders.

Authors:  Sonja W Scholz; Jose Bras
Journal:  Int J Mol Sci       Date:  2015-10-16       Impact factor: 5.923

7.  Genetic variants in diseases of the extrapyramidal system.

Authors:  Anna Oczkowska; Wojciech Kozubski; Margarita Lianeri; Jolanta Dorszewska
Journal:  Curr Genomics       Date:  2014-02       Impact factor: 2.236

8.  Altered lipid levels provide evidence for myelin dysfunction in multiple system atrophy.

Authors:  Anthony S Don; Jen-Hsiang T Hsiao; Jonathan M Bleasel; Timothy A Couttas; Glenda M Halliday; Woojin Scott Kim
Journal:  Acta Neuropathol Commun       Date:  2014-10-29       Impact factor: 7.801

9.  SNCA variants are associated with increased risk for multiple system atrophy.

Authors:  Sonja W Scholz; Henry Houlden; Claudia Schulte; Manu Sharma; Abi Li; Daniela Berg; Anna Melchers; Reema Paudel; J Raphael Gibbs; Javier Simon-Sanchez; Coro Paisan-Ruiz; Jose Bras; Jinhui Ding; Honglei Chen; Bryan J Traynor; Sampath Arepalli; Ryan R Zonozi; Tamas Revesz; Janice Holton; Nick Wood; Andrew Lees; Wolfgang Oertel; Ullrich Wüllner; Stefano Goldwurm; Maria Teresa Pellecchia; Thomas Illig; Olaf Riess; Hubert H Fernandez; Ramon L Rodriguez; Michael S Okun; Werner Poewe; Gregor K Wenning; John A Hardy; Andrew B Singleton; Francesca Del Sorbo; Susanne Schneider; Kailash P Bhatia; Thomas Gasser
Journal:  Ann Neurol       Date:  2009-05       Impact factor: 10.422

Review 10.  Multiple system atrophy: the application of genetics in understanding etiology.

Authors:  Monica Federoff; Lucia V Schottlaender; Henry Houlden; Andrew Singleton
Journal:  Clin Auton Res       Date:  2015-02-17       Impact factor: 4.435
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