Literature DB >> 11563635

Analysis of the expression level of alpha-synuclein mRNA using postmortem brain samples from pathologically confirmed cases of multiple system atrophy.

T Ozawa1, K Okuizumi, T Ikeuchi, K Wakabayashi, H Takahashi, S Tsuji.   

Abstract

To determine whether multiple system atrophy (MSA) is associated with altered expression levels of the alpha-synuclein messenger RNA (mRNA), we performed quantitative reverse transcription polymerase chain reaction for alpha-synuclein mRNA using postmortem brain samples from 11 cases of MSA and 14 age-matched control subjects. The brain specimens used in this study contained both the gray matter and white matter, which were dissected from the frontal, temporal or occipital lobe. The expression levels of alpha-synuclein mRNA in the brain specimens of MSA cases were not different from those of the control subjects. These results suggest that the transcriptional regulation of the alpha-synuclein gene is unlikely to be affected in MSA brains.

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Year:  2001        PMID： 11563635     DOI： 10.1007/s004010100367

Source DB:  PubMed          Journal:  Acta Neuropathol        ISSN： 0001-6322            Impact factor:   17.088


  43 in total

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Authors:  Kiren Ubhi; Phillip Low; Eliezer Masliah
Journal:  Trends Neurosci       Date:  2011-09-29       Impact factor: 13.837

Review 2.  Novel therapeutic approaches in multiple system atrophy.

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Review 3.  Review: Novel treatment strategies targeting alpha-synuclein in multiple system atrophy as a model of synucleinopathy.

Authors:  E Valera; G Monzio Compagnoni; E Masliah
Journal:  Neuropathol Appl Neurobiol       Date:  2016-02       Impact factor: 8.090

Review 4.  α-Synuclein: Multiple System Atrophy Prions.

Authors:  Amanda L Woerman; Joel C Watts; Atsushi Aoyagi; Kurt Giles; Lefkos T Middleton; Stanley B Prusiner
Journal:  Cold Spring Harb Perspect Med       Date:  2018-07-02       Impact factor: 6.915

Review 5.  The neuropathology of multiple system atrophy and its therapeutic implications.

Authors:  Elvira Valera; Eliezer Masliah
Journal:  Auton Neurosci       Date:  2017-11-10       Impact factor: 3.145

6.  Hyperphosphorylation and insolubility of alpha-synuclein in transgenic mouse oligodendrocytes.

Authors:  Philipp J Kahle; Manuela Neumann; Laurence Ozmen; Veronika Muller; Helmut Jacobsen; Will Spooren; Babette Fuss; Barbara Mallon; Wendy B Macklin; Hideo Fujiwara; Masato Hasegawa; Takeshi Iwatsubo; Hans A Kretzschmar; Christian Haass
Journal:  EMBO Rep       Date:  2002-05-24       Impact factor: 8.807

7.  Absence of alpha-synuclein mRNA expression in normal and multiple system atrophy oligodendroglia.

Authors:  D W Miller; J M Johnson; S M Solano; Z R Hollingsworth; D G Standaert; A B Young
Journal:  J Neural Transm (Vienna)       Date:  2005-12       Impact factor: 3.575

8.  Transcriptome analysis of grey and white matter cortical tissue in multiple system atrophy.

Authors:  James D Mills; Woojin S Kim; Glenda M Halliday; Michael Janitz
Journal:  Neurogenetics       Date:  2014-11-06       Impact factor: 2.660

9.  Expanding the spectrum of neuronal pathology in multiple system atrophy.

Authors:  Matthew D Cykowski; Elizabeth A Coon; Suzanne Z Powell; Sarah M Jenkins; Eduardo E Benarroch; Phillip A Low; Ann M Schmeichel; Joseph E Parisi
Journal:  Brain       Date:  2015-05-16       Impact factor: 13.501

Review 10.  Multiple system atrophy: experimental models and reality.

Authors:  Cassia Overk; Edward Rockenstein; Elvira Valera; Nadia Stefanova; Gregor Wenning; Eliezer Masliah
Journal:  Acta Neuropathol       Date:  2017-10-20       Impact factor: 17.088
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