Literature DB >> 19473830

Designing switchable enzymes.

Marc Ostermeier1.   

Abstract

The modulation of enzyme function is a key regulatory feature of biological systems. The ability to engineer synthetic enzymes that can be controlled by any arbitrary signal would enable a wide array of sensing applications and therapeutics and provide us with powerful tools for the basic study of biology. Here several recent advances in the engineering of switchable enzymes through domain fusion are discussed.

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Year:  2009        PMID： 19473830      PMCID： PMC2736331          DOI： 10.1016/j.sbi.2009.04.007

Source DB:  PubMed          Journal:  Curr Opin Struct Biol        ISSN： 0959-440X            Impact factor:   6.809


  30 in total

1.  Circular permutation and receptor insertion within green fluorescent proteins.

Authors:  G S Baird; D A Zacharias; R Y Tsien
Journal:  Proc Natl Acad Sci U S A       Date:  1999-09-28       Impact factor: 11.205

2.  Functionally accepted insertions of proteins within protein domains.

Authors:  B Collinet; M Herve; F Pecorari; P Minard; O Eder; M Desmadril
Journal:  J Biol Chem       Date:  2000-06-09       Impact factor: 5.157

Review 3.  Phytochrome photosensory signalling networks.

Authors:  Peter H Quail
Journal:  Nat Rev Mol Cell Biol       Date:  2002-02       Impact factor: 94.444

4.  Evolutionarily conserved networks of residues mediate allosteric communication in proteins.

Authors:  Gürol M Süel; Steve W Lockless; Mark A Wall; Rama Ranganathan
Journal:  Nat Struct Biol       Date:  2003-01

5.  Reprogramming control of an allosteric signaling switch through modular recombination.

Authors:  John E Dueber; Brian J Yeh; Kayam Chak; Wendell A Lim
Journal:  Science       Date:  2003-09-26       Impact factor: 47.728

6.  Allosteric switching by mutually exclusive folding of protein domains.

Authors:  Tracy L Radley; Anna I Markowska; Blaine T Bettinger; Jeung-Hoi Ha; Stewart N Loh
Journal:  J Mol Biol       Date:  2003-09-19       Impact factor: 5.469

7.  The interaction of Arp2/3 complex with actin: nucleation, high affinity pointed end capping, and formation of branching networks of filaments.

Authors:  R D Mullins; J A Heuser; T D Pollard
Journal:  Proc Natl Acad Sci U S A       Date:  1998-05-26       Impact factor: 11.205

8.  Crystal structure of firefly luciferase throws light on a superfamily of adenylate-forming enzymes.

Authors:  E Conti; N P Franks; P Brick
Journal:  Structure       Date:  1996-03-15       Impact factor: 5.006

9.  Effect of interdomain linker length on an antagonistic folding-unfolding equilibrium between two protein domains.

Authors:  Thomas A Cutler; Brandon M Mills; David J Lubin; Lillian T Chong; Stewart N Loh
Journal:  J Mol Biol       Date:  2008-11-08       Impact factor: 5.469

10.  Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue.

Authors:  J Chen; X F Zheng; E J Brown; S L Schreiber
Journal:  Proc Natl Acad Sci U S A       Date:  1995-05-23       Impact factor: 11.205
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  29 in total

1.  Designing redox potential-controlled protein switches based on mutually exclusive proteins.

Authors:  Qing Peng; Na Kong; Hui-Chuan Eileen Wang; Hongbin Li
Journal:  Protein Sci       Date:  2012-08       Impact factor: 6.725

Review 2.  Converting a protein into a switch for biosensing and functional regulation.

Authors:  Margaret M Stratton; Stewart N Loh
Journal:  Protein Sci       Date:  2011-01       Impact factor: 6.725

3.  A protein switch sensing system for the quantification of sulfate.

Authors:  Krystal Teasley Hamorsky; Charles Mark Ensor; Patrizia Pasini; Sylvia Daunert
Journal:  Anal Biochem       Date:  2011-10-18       Impact factor: 3.365

Review 4.  Unparalleled control of neural activity using orthogonal pharmacogenetics.

Authors:  Mikhail G Shapiro; Shawnalea J Frazier; Henry A Lester
Journal:  ACS Chem Neurosci       Date:  2012-06-01       Impact factor: 4.418

5.  Molecular simulations of mutually exclusive folding in a two-domain protein switch.

Authors:  Brandon M Mills; Lillian T Chong
Journal:  Biophys J       Date:  2011-02-02       Impact factor: 4.033

Review 6.  Structure-switching biosensors: inspired by Nature.

Authors:  Alexis Vallée-Bélisle; Kevin W Plaxco
Journal:  Curr Opin Struct Biol       Date:  2010-06-02       Impact factor: 6.809

7.  Reprogramming EF-hands for design of catalytically amplified lanthanide sensors.

Authors:  Korrie L Mack; Olesia V Moroz; Yurii S Moroz; Alissa B Olsen; Jaclyn M McLaughlin; Ivan V Korendovych
Journal:  J Biol Inorg Chem       Date:  2013-02-19       Impact factor: 3.358

8.  Rational design of a ligand-controlled protein conformational switch.

Authors:  Onur Dagliyan; David Shirvanyants; Andrei V Karginov; Feng Ding; Lanette Fee; Srinivas N Chandrasekaran; Christina M Freisinger; Gromoslaw A Smolen; Anna Huttenlocher; Klaus M Hahn; Nikolay V Dokholyan
Journal:  Proc Natl Acad Sci U S A       Date:  2013-04-08       Impact factor: 11.205

9.  Thermodynamic basis for engineering high-affinity, high-specificity binding-induced DNA clamp nanoswitches.

Authors:  Andrea Idili; Kevin W Plaxco; Alexis Vallée-Bélisle; Francesco Ricci
Journal:  ACS Nano       Date:  2013-11-20       Impact factor: 15.881

Review 10.  Strategies for protein synthetic biology.

Authors:  Raik Grünberg; Luis Serrano
Journal:  Nucleic Acids Res       Date:  2010-04-12       Impact factor: 16.971
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