Literature DB >> 19451641

A central role for venom in predation by Varanus komodoensis (Komodo Dragon) and the extinct giant Varanus (Megalania) priscus.

Bryan G Fry1, Stephen Wroe, Wouter Teeuwisse, Matthias J P van Osch, Karen Moreno, Janette Ingle, Colin McHenry, Toni Ferrara, Phillip Clausen, Holger Scheib, Kelly L Winter, Laura Greisman, Kim Roelants, Louise van der Weerd, Christofer J Clemente, Eleni Giannakis, Wayne C Hodgson, Sonja Luz, Paolo Martelli, Karthiyani Krishnasamy, Elazar Kochva, Hang Fai Kwok, Denis Scanlon, John Karas, Diane M Citron, Ellie J C Goldstein, Judith E McNaughtan, Janette A Norman.   

Abstract

The predatory ecology of Varanus komodoensis (Komodo Dragon) has been a subject of long-standing interest and considerable conjecture. Here, we investigate the roles and potential interplay between cranial mechanics, toxic bacteria, and venom. Our analyses point to the presence of a sophisticated combined-arsenal killing apparatus. We find that the lightweight skull is relatively poorly adapted to generate high bite forces but better adapted to resist high pulling loads. We reject the popular notion regarding toxic bacteria utilization. Instead, we demonstrate that the effects of deep wounds inflicted are potentiated through venom with toxic activities including anticoagulation and shock induction. Anatomical comparisons of V. komodoensis with V. (Megalania) priscus fossils suggest that the closely related extinct giant was the largest venomous animal to have ever lived.

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Year:  2009        PMID: 19451641      PMCID: PMC2690028          DOI: 10.1073/pnas.0810883106

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN: 0027-8424            Impact factor:   11.205


  22 in total

1.  Influences on venom yield in Australian tigersnakes (Notechis scutatus) and brownsnakes (Pseudonaja textilis: Elapidae, Serpentes).

Authors:  P J Mirtschin; R Shine; T J Nias; N L Dunstan; B J Hough; M Mirtschin
Journal:  Toxicon       Date:  2002-11       Impact factor: 3.033

2.  Novel natriuretic peptides from the venom of the inland taipan (Oxyuranus microlepidotus): isolation, chemical and biological characterisation.

Authors:  Bryan G Fry; Janith C Wickramaratana; Scott Lemme; Anne Beuve; David Garbers; Wayne C Hodgson; Paul Alewood
Journal:  Biochem Biophys Res Commun       Date:  2005-02-25       Impact factor: 3.575

3.  From genome to "venome": molecular origin and evolution of the snake venom proteome inferred from phylogenetic analysis of toxin sequences and related body proteins.

Authors:  Bryan G Fry
Journal:  Genome Res       Date:  2005-03       Impact factor: 9.043

4.  Pasteurella multocida infection after a Tasmanian devil bite.

Authors:  P R Georghiou; T F Mollee; M H Tilse
Journal:  Clin Infect Dis       Date:  1992-06       Impact factor: 9.079

5.  Protein nature and some enzymatic properties of the lizard Heloderma suspectum suspectum (Gila monster) venom.

Authors:  A T Tu; D S Murdock
Journal:  Comp Biochem Physiol       Date:  1967-08

6.  Metabolic efficiency and amino acid composition in the proteomes of Escherichia coli and Bacillus subtilis.

Authors:  Hiroshi Akashi; Takashi Gojobori
Journal:  Proc Natl Acad Sci U S A       Date:  2002-03-19       Impact factor: 11.205

7.  Eggs-only diet: its implications for the toxin profile changes and ecology of the marbled sea snake (Aipysurus eydouxii).

Authors:  Min Li; B G Fry; R Manjunatha Kini
Journal:  J Mol Evol       Date:  2005-01       Impact factor: 2.395

8.  Aerobic bacterial oral flora of garter snakes: development of normal flora and pathogenic potential for snakes and humans.

Authors:  E J Goldstein; E O Agyare; A E Vagvolgyi; M Halpern
Journal:  J Clin Microbiol       Date:  1981-05       Impact factor: 5.948

9.  Delivery of Duvernoy's secretion into prey by the brown tree snake, Boiga irregularis (Serpentes:Colubridae).

Authors:  W K Hayes; P Lavín-Murcio; K V Kardong
Journal:  Toxicon       Date:  1993-07       Impact factor: 3.033

10.  Analysis of Colubroidea snake venoms by liquid chromatography with mass spectrometry: evolutionary and toxinological implications.

Authors:  Bryan G Fry; Wolfgang Wüster; Sheik Fadil Ryan Ramjan; Timothy Jackson; Paolo Martelli; R Manjunatha Kini
Journal:  Rapid Commun Mass Spectrom       Date:  2003       Impact factor: 2.419

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  29 in total

1.  Proteome of Hydra nematocyst.

Authors:  Prakash G Balasubramanian; Anna Beckmann; Uwe Warnken; Martina Schnölzer; Andreas Schüler; Erich Bornberg-Bauer; Thomas W Holstein; Suat Ozbek
Journal:  J Biol Chem       Date:  2012-01-30       Impact factor: 5.157

2.  Functional and structural diversification of the Anguimorpha lizard venom system.

Authors:  Bryan G Fry; Kelly Winter; Janette A Norman; Kim Roelants; Rob J A Nabuurs; Matthias J P van Osch; Wouter M Teeuwisse; Louise van der Weerd; Judith E McNaughtan; Hang Fai Kwok; Holger Scheib; Laura Greisman; Elazar Kochva; Laurence J Miller; Fan Gao; John Karas; Denis Scanlon; Feng Lin; Sanjaya Kuruppu; Chris Shaw; Lily Wong; Wayne C Hodgson
Journal:  Mol Cell Proteomics       Date:  2010-07-14       Impact factor: 5.911

3.  Grooves to tubes: evolution of the venom delivery system in a Late Triassic "reptile".

Authors:  Jonathan S Mitchell; Andrew B Heckert; Hans-Dieter Sues
Journal:  Naturwissenschaften       Date:  2010-12

4.  The birdlike raptor Sinornithosaurus was venomous.

Authors:  Enpu Gong; Larry D Martin; David A Burnham; Amanda R Falk
Journal:  Proc Natl Acad Sci U S A       Date:  2009-12-22       Impact factor: 11.205

5.  Climate change frames debate over the extinction of megafauna in Sahul (Pleistocene Australia-New Guinea).

Authors:  Stephen Wroe; Judith H Field; Michael Archer; Donald K Grayson; Gilbert J Price; Julien Louys; J Tyler Faith; Gregory E Webb; Iain Davidson; Scott D Mooney
Journal:  Proc Natl Acad Sci U S A       Date:  2013-05-06       Impact factor: 11.205

6.  Structural and molecular diversification of the Anguimorpha lizard mandibular venom gland system in the arboreal species Abronia graminea.

Authors:  Ivan Koludarov; Kartik Sunagar; Eivind A B Undheim; Timothy N W Jackson; Tim Ruder; Darryl Whitehead; Alejandro C Saucedo; G Roberto Mora; Alejandro C Alagon; Glenn King; Agostinho Antunes; Bryan G Fry
Journal:  J Mol Evol       Date:  2012-11-17       Impact factor: 2.395

7.  Dynamic evolution of venom proteins in squamate reptiles.

Authors:  Nicholas R Casewell; Gavin A Huttley; Wolfgang Wüster
Journal:  Nat Commun       Date:  2012       Impact factor: 14.919

8.  Computational biomechanical analyses demonstrate similar shell-crushing abilities in modern and ancient arthropods.

Authors:  Russell D C Bicknell; Justin A Ledogar; Stephen Wroe; Benjamin C Gutzler; Winsor H Watson; John R Paterson
Journal:  Proc Biol Sci       Date:  2018-10-24       Impact factor: 5.349

9.  Deathly drool: evolutionary and ecological basis of septic bacteria in Komodo dragon mouths.

Authors:  J J Bull; Tim S Jessop; Marvin Whiteley
Journal:  PLoS One       Date:  2010-06-21       Impact factor: 3.240

10.  Diversity, phylogenetic distribution, and origins of venomous catfishes.

Authors:  Jeremy J Wright
Journal:  BMC Evol Biol       Date:  2009-12-04       Impact factor: 3.260

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