OBJECTIVE: Anomalies of the corpus callosum are frequently diagnosed during pregnancy, but a thick corpus callosum is a rare finding and its significance is not clear. We aimed to assess the significance of thick fetal corpus callosum by reviewing our experience of such cases. METHODS: The records of all fetuses with anomalies of the corpus callosum referred to the prenatal diagnosis units of two university hospitals from 2000 to 2007 were reviewed. Nine fetuses with a thick corpus callosum were identified. RESULTS: In all cases there were associated abnormalities: macrocephaly, ventriculomegaly, vermian agenesis, abnormal sulcation or encephalocele. Four pregnancies were terminated and in each of these cases the autopsy confirmed dysmorphic features and additional brain abnormalities. Five infants were delivered; two died shortly after birth, one suffers from mental retardation, one had neonatal convulsions and one is developing normally. CONCLUSIONS: A thick fetal corpus callosum is usually associated with other brain anomalies and is part of a neurogenetic syndrome in most cases. (c) 2009 ISUOG.
OBJECTIVE: Anomalies of the corpus callosum are frequently diagnosed during pregnancy, but a thick corpus callosum is a rare finding and its significance is not clear. We aimed to assess the significance of thick fetal corpus callosum by reviewing our experience of such cases. METHODS: The records of all fetuses with anomalies of the corpus callosum referred to the prenatal diagnosis units of two university hospitals from 2000 to 2007 were reviewed. Nine fetuses with a thick corpus callosum were identified. RESULTS: In all cases there were associated abnormalities: macrocephaly, ventriculomegaly, vermian agenesis, abnormal sulcation or encephalocele. Four pregnancies were terminated and in each of these cases the autopsy confirmed dysmorphic features and additional brain abnormalities. Five infants were delivered; two died shortly after birth, one suffers from mental retardation, one had neonatal convulsions and one is developing normally. CONCLUSIONS: A thick fetal corpus callosum is usually associated with other brain anomalies and is part of a neurogenetic syndrome in most cases. (c) 2009 ISUOG.
Authors: S A Mandelstam; R J Leventer; A Sandow; G McGillivray; M van Kogelenberg; R Guerrini; S Robertson; S F Berkovic; G D Jackson; I E Scheffer Journal: AJNR Am J Neuroradiol Date: 2013-01-24 Impact factor: 3.825
Authors: Yada Kunpalin; Jan Deprest; Ioannis Papastefanou; Emma Bredaki; Adalina Sacco; Francesca Russo; Jute Richter; Katrien Jansen; Sebastien Ourselin; Paolo De Coppi; Anna L David; Fred Ushakov; Luc De Catte Journal: Prenat Diagn Date: 2021-04-08 Impact factor: 3.242
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