BACKGROUND: The association between nodal ratio and survival in oral cavity carcinomas has recently been proposed, but no prospective evaluations exist. METHODS: We sought to determine, using an institutional database, whether nodal ratio impacts survival in node-positive oral cavity squamous cell carcinoma. RESULTS: Between 1994 and 2004, 143 new diagnoses of N(1-2) squamous cell carcinoma of the oral cavity were identified. The mean number of nodes identified was 41.6, and the mean nodal ratio was 9%. Nodal ratio was strongly statistically associated with overall and disease-specific survival in both univariate and multivariate analyses. No other prognostic indicator maintained that degree of statistical significance. Patients could be stratified into low (0% to 6%), moderate (6% to 13%), and high-risk (>13%) groups based on nodal ratio. CONCLUSIONS: In squamous cell carcinoma of the oral cavity, an increased nodal ratio is a strong predictor of decreased survival. Risk of death can be stratified by nodal ratio. (c) 2009 Wiley Periodicals, Inc. Head Neck, 2009.
BACKGROUND: The association between nodal ratio and survival in oral cavity carcinomas has recently been proposed, but no prospective evaluations exist. METHODS: We sought to determine, using an institutional database, whether nodal ratio impacts survival in node-positive oral cavity squamous cell carcinoma. RESULTS: Between 1994 and 2004, 143 new diagnoses of N(1-2) squamous cell carcinoma of the oral cavity were identified. The mean number of nodes identified was 41.6, and the mean nodal ratio was 9%. Nodal ratio was strongly statistically associated with overall and disease-specific survival in both univariate and multivariate analyses. No other prognostic indicator maintained that degree of statistical significance. Patients could be stratified into low (0% to 6%), moderate (6% to 13%), and high-risk (>13%) groups based on nodal ratio. CONCLUSIONS: In squamous cell carcinoma of the oral cavity, an increased nodal ratio is a strong predictor of decreased survival. Risk of death can be stratified by nodal ratio. (c) 2009 Wiley Periodicals, Inc. Head Neck, 2009.
Authors: Vasu Divi; Jonathan Harris; Paul M Harari; Jay S Cooper; Jonathan McHugh; Diana Bell; Erich M Sturgis; Anthony J Cmelak; Mohan Suntharalingam; David Raben; Harold Kim; Sharon A Spencer; George E Laramore; Andy Trotti; Robert L Foote; Christopher Schultz; Wade L Thorstad; Qiang Ed Zhang; Quynh Thu Le; F Christopher Holsinger Journal: Cancer Date: 2016-07-15 Impact factor: 6.860
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