Literature DB >> 19435667

Identification of Hsp70 modulators through modeling of the substrate binding domain.

Conor M Haney1, Corinne Schneider, Barbara Beck, Jeffrey L Brodsky, Alexander Dömling.   

Abstract

The design, synthesis and preliminary activity of small molecular weight modulators of the heat shock protein 70 (Hsp70) are described. The compounds provide a starting point for the synthesis of novel tools to decipher Hsp70 biology.

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Year:  2009        PMID： 19435667      PMCID： PMC8894028          DOI： 10.1016/j.bmcl.2009.04.062

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  26 in total

1.  Mutations in the substrate binding domain of the Escherichia coli 70 kDa molecular chaperone, DnaK, which alter substrate affinity or interdomain coupling.

Authors:  D L Montgomery; R I Morimoto; L M Gierasch
Journal:  J Mol Biol       Date:  1999-02-26       Impact factor: 5.469

2.  Multicomponent Reactions with Isocyanides.

Authors: 
Journal:  Angew Chem Int Ed Engl       Date:  2000-09-15       Impact factor: 15.336

3.  Small molecule modulators of endogenous and co-chaperone-stimulated Hsp70 ATPase activity.

Authors:  Sheara W Fewell; Christine M Smith; Michael A Lyon; Teodora Pene Dumitrescu; Peter Wipf; Billy W Day; Jeffrey L Brodsky
Journal:  J Biol Chem       Date:  2004-09-23       Impact factor: 5.157

Review 4.  The Hsp70 and Hsp60 chaperone machines.

Authors:  B Bukau; A L Horwich
Journal:  Cell       Date:  1998-02-06       Impact factor: 41.582

5.  Structural analysis of substrate binding by the molecular chaperone DnaK.

Authors:  X Zhu; X Zhao; W F Burkholder; A Gragerov; C M Ogata; M E Gottesman; W A Hendrickson
Journal:  Science       Date:  1996-06-14       Impact factor: 47.728

6.  MAB, a generally applicable molecular force field for structure modelling in medicinal chemistry.

Authors:  P R Gerber; K Müller
Journal:  J Comput Aided Mol Des       Date:  1995-06       Impact factor: 3.686

7.  Neuroprotective effects of HSP70 overexpression after cerebral ischaemia--an MRI study.

Authors:  Louise van der Weerd; Mark F Lythgoe; Romina Aron Badin; Lauren M Valentim; Mohammed Tariq Akbar; Jackie S de Belleroche; David S Latchman; David G Gadian
Journal:  Exp Neurol       Date:  2005-09       Impact factor: 5.330

8.  High levels of heat shock protein Hsp72 in cancer cells suppress default senescence pathways.

Authors:  Julia A Yaglom; Vladimir L Gabai; Michael Y Sherman
Journal:  Cancer Res       Date:  2007-03-01       Impact factor: 12.701

Review 9.  Hsp70 molecular chaperones: emerging roles in human disease and identification of small molecule modulators.

Authors:  Jeffrey L Brodsky; Gabriela Chiosis
Journal:  Curr Top Med Chem       Date:  2006       Impact factor: 3.295

Review 10.  The structural and functional diversity of Hsp70 proteins from Plasmodium falciparum.

Authors:  Addmore Shonhai; Aileen Boshoff; Gregory L Blatch
Journal:  Protein Sci       Date:  2007-09       Impact factor: 6.725
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  6 in total

Review 1.  Chemistry and biology of multicomponent reactions.

Authors:  Alexander Dömling; Wei Wang; Kan Wang
Journal:  Chem Rev       Date:  2012-03-22       Impact factor: 60.622

Review 2.  Heat shock protein 70 (hsp70) as an emerging drug target.

Authors:  Christopher G Evans; Lyra Chang; Jason E Gestwicki
Journal:  J Med Chem       Date:  2010-06-24       Impact factor: 7.446

Review 3.  Molecular chaperones and regulation of tau quality control: strategies for drug discovery in tauopathies.

Authors:  Yoshinari Miyata; John Koren; Janine Kiray; Chad A Dickey; Jason E Gestwicki
Journal:  Future Med Chem       Date:  2011-09       Impact factor: 3.808

4.  Identification of an allosteric pocket on human hsp70 reveals a mode of inhibition of this therapeutically important protein.

Authors:  Anna Rodina; Pallav D Patel; Yanlong Kang; Yogita Patel; Imad Baaklini; Michael J H Wong; Tony Taldone; Pengrong Yan; Chenghua Yang; Ronnie Maharaj; Alexander Gozman; Maulik R Patel; Hardik J Patel; William Chirico; Hediye Erdjument-Bromage; Tanaji T Talele; Jason C Young; Gabriela Chiosis
Journal:  Chem Biol       Date:  2013-11-14

Review 5.  Pharmacological targeting of the Hsp70 chaperone.

Authors:  Srikanth Patury; Yoshinari Miyata; Jason E Gestwicki
Journal:  Curr Top Med Chem       Date:  2009       Impact factor: 3.295

6.  Investigating Apoptozole as a Chemical Probe for HSP70 Inhibition.

Authors:  Lindsay E Evans; Matthew D Cheeseman; Norhakim Yahya; Keith Jones
Journal:  PLoS One       Date:  2015-10-12       Impact factor: 3.240
  6 in total

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