Literature DB >> 20334364

Heat shock protein 70 (hsp70) as an emerging drug target.

Christopher G Evans1, Lyra Chang, Jason E Gestwicki.   

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Year:  2010        PMID： 20334364      PMCID： PMC2895966          DOI： 10.1021/jm100054f

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  236 in total

1.  Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins.

Authors:  S Krobitsch; S Lindquist
Journal:  Proc Natl Acad Sci U S A       Date:  2000-02-15       Impact factor: 11.205

2.  Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity.

Authors:  N R Jana; M Tanaka; G h Wang; N Nukina
Journal:  Hum Mol Genet       Date:  2000-08-12       Impact factor: 6.150

3.  Polyglutamine expansion induces a protein-damaging stress connecting heat shock protein 70 to the JNK pathway.

Authors:  Karine Merienne; Dominique Helmlinger; Gordon R Perkin; Didier Devys; Yvon Trottier
Journal:  J Biol Chem       Date:  2003-02-21       Impact factor: 5.157

4.  Hsp72 and stress kinase c-jun N-terminal kinase regulate the bid-dependent pathway in tumor necrosis factor-induced apoptosis.

Authors:  Vladimir L Gabai; Katsuhide Mabuchi; Dick D Mosser; Michael Y Sherman
Journal:  Mol Cell Biol       Date:  2002-05       Impact factor: 4.272

5.  Role for dnaK locus in tolerance of multiple stresses in Staphylococcus aureus.

Authors:  Vineet K Singh; Sugunya Utaida; Letitia S Jackson; R K Jayaswal; Brian J Wilkinson; Neal R Chamberlain
Journal:  Microbiology       Date:  2007-09       Impact factor: 2.777

6.  U-box protein carboxyl terminus of Hsc70-interacting protein (CHIP) mediates poly-ubiquitylation preferentially on four-repeat Tau and is involved in neurodegeneration of tauopathy.

Authors:  Shigetsugu Hatakeyama; Masaki Matsumoto; Takumi Kamura; Miyuki Murayama; Du-Hua Chui; Emmanuel Planel; Ryosuke Takahashi; Keiichi I Nakayama; Akihiko Takashima
Journal:  J Neurochem       Date:  2004-10       Impact factor: 5.372

7.  MKT-077, a novel rhodacyanine dye in clinical trials, exhibits anticarcinoma activity in preclinical studies based on selective mitochondrial accumulation.

Authors:  K Koya; Y Li; H Wang; T Ukai; N Tatsuta; M Kawakami; L B Chen
Journal:  Cancer Res       Date:  1996-02-01       Impact factor: 12.701

8.  Identification of a binding site on Hsc70 for the immunosuppressant 15-deoxyspergualin.

Authors:  S G Nadler; D D Dischino; A R Malacko; J S Cleaveland; S M Fujihara; H Marquardt
Journal:  Biochem Biophys Res Commun       Date:  1998-12-09       Impact factor: 3.575

9.  HSP70 protects BCL2L12 and BCL2L12A from N-terminal ubiquitination-mediated proteasomal degradation.

Authors:  Junwu Yang; Yi Hong; Wenzong Wang; Weibing Wu; Yayun Chi; Hongliang Zong; Xiangfei Kong; Yuanyan Wei; Xiaojing Yun; Chunming Cheng; Kangli Chen; Jianxin Gu
Journal:  FEBS Lett       Date:  2009-04-18       Impact factor: 4.124

10.  Short peptides derived from the BAG-1 C-terminus inhibit the interaction between BAG-1 and HSC70 and decrease breast cancer cell growth.

Authors:  Adam Sharp; Ramsey I Cutress; Peter W M Johnson; Graham Packham; Paul A Townsend
Journal:  FEBS Lett       Date:  2009-10-01       Impact factor: 4.124
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  178 in total

1.  HSP70 inhibition by the small-molecule 2-phenylethynesulfonamide impairs protein clearance pathways in tumor cells.

Authors:  J I-Ju Leu; Julia Pimkina; Pooja Pandey; Maureen E Murphy; Donna L George
Journal:  Mol Cancer Res       Date:  2011-06-02       Impact factor: 5.852

2.  Visualization and functional analysis of the oligomeric states of Escherichia coli heat shock protein 70 (Hsp70/DnaK).

Authors:  Andrea D Thompson; Steffen M Bernard; Georgios Skiniotis; Jason E Gestwicki
Journal:  Cell Stress Chaperones       Date:  2011-11-11       Impact factor: 3.667

3.  Inhibition of heat shock transcription factor binding by a linear polyamide binding in an unusual 1:1 mode.

Authors:  Rongsheng E Wang; Raj K Pandita; Jianfeng Cai; Clayton R Hunt; John-Stephen Taylor
Journal:  Chembiochem       Date:  2011-12-01       Impact factor: 3.164

4.  Unique peptide substrate binding properties of 110-kDa heat-shock protein (Hsp110) determine its distinct chaperone activity.

Authors:  Xinping Xu; Evans Boateng Sarbeng; Christina Vorvis; Divya Prasanna Kumar; Lei Zhou; Qinglian Liu
Journal:  J Biol Chem       Date:  2011-12-08       Impact factor: 5.157

5.  Apoptosis induced by ZnPcH1-based photodynamic therapy in Jurkat cells and HEL cells.

Authors:  Huifang Huang; Xiaoyan Zhao; Yuanzhong Chen; Rong Lu; Yong Wu
Journal:  Int J Hematol       Date:  2011-11-17       Impact factor: 2.490

Review 6.  Natural products as chemical probes.

Authors:  Erin E Carlson
Journal:  ACS Chem Biol       Date:  2010-07-16       Impact factor: 5.100

7.  Identification and expression analysis of a heat-shock protein 70 gene in Polycelis sp.

Authors:  Fangfang Cheng; Zimei Dong; Yanping Dong; Yingxu Sima; Jing Chen; Xiaoyan Li; Guangwen Chen; Dezeng Liu
Journal:  Cell Stress Chaperones       Date:  2015-08-27       Impact factor: 3.667

8.  Hydroxybiphenylamide GroEL/ES Inhibitors Are Potent Antibacterials against Planktonic and Biofilm Forms of Staphylococcus aureus.

Authors:  Trent Kunkle; Sanofar Abdeen; Nilshad Salim; Anne-Marie Ray; Mckayla Stevens; Andrew J Ambrose; José Victorino; Yangshin Park; Quyen Q Hoang; Eli Chapman; Steven M Johnson
Journal:  J Med Chem       Date:  2018-11-15       Impact factor: 7.446

9.  Mutations in the Yeast Hsp70, Ssa1, at P417 Alter ATP Cycling, Interdomain Coupling, and Specific Chaperone Functions.

Authors:  Patrick G Needham; Hardik J Patel; Gabriela Chiosis; Patrick H Thibodeau; Jeffrey L Brodsky
Journal:  J Mol Biol       Date:  2015-04-23       Impact factor: 5.469

Review 10.  Expanding the number of 'druggable' targets: non-enzymes and protein-protein interactions.

Authors:  Leah N Makley; Jason E Gestwicki
Journal:  Chem Biol Drug Des       Date:  2013-01       Impact factor: 2.817
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