Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Towards better mouse models: enhanced genotypes, systemic phenotyping and envirotype modelling.

Literature DB >> 19434078

Towards better mouse models: enhanced genotypes, systemic phenotyping and envirotype modelling.

Johannes Beckers¹, Wolfgang Wurst, Martin Hrabé de Angelis.

Abstract

The mouse is the leading mammalian model organism for basic genetic research and for studying human diseases. Coordinated international projects are currently in progress to generate a comprehensive map of mouse gene functions - the first for any mammalian genome. There are still many challenges ahead to maximize the value of the mouse as a model, particularly for human disease. These involve generating mice that are better models of human diseases at the genotypic level, systemic (assessing all organ systems) and systematic (analysing all mouse lines) phenotyping of existing and new mouse mutant resources, and assessing the effects of the environment on phenotypes.

Entities: Species

Mesh：

Year: 2009 PMID： 19434078 DOI： 10.1038/nrg2578

Source DB: PubMed Journal: Nat Rev Genet ISSN： 1471-0056 Impact factor: 53.242

108 in total

1. Development of a human adaptive immune system in cord blood cell-transplanted mice.

Authors: Elisabetta Traggiai; Laurie Chicha; Luca Mazzucchelli; Lucio Bronz; Jean-Claude Piffaretti; Antonio Lanzavecchia; Markus G Manz
Journal: Science Date: 2004-04-02 Impact factor: 47.728

2. FIMRe: Federation of International Mouse Resources: global networking of resource centers.

Authors: Muriel Davisson
Journal: Mamm Genome Date: 2006-05 Impact factor: 2.957

3. Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS.

Authors: Cédric Raoul; Toufik Abbas-Terki; Jean-Charles Bensadoun; Sandrine Guillot; Georg Haase; Jolanta Szulc; Christopher E Henderson; Patrick Aebischer
Journal: Nat Med Date: 2005-03-13 Impact factor: 53.440

4. Reconstruction of human mammary tissues in a mouse model.

Authors: David A Proia; Charlotte Kuperwasser
Journal: Nat Protoc Date: 2006 Impact factor: 13.491

5. Beethoven, a mouse model for dominant, progressive hearing loss DFNA36.

Authors: Sarah Vreugde; Alexandra Erven; Corné J Kros; Walter Marcotti; Helmut Fuchs; Kiyoto Kurima; Edward R Wilcox; Thomas B Friedman; Andrew J Griffith; Rudi Balling; Martin Hrabé De Angelis; Karen B Avraham; Karen P Steel
Journal: Nat Genet Date: 2002-02-19 Impact factor: 38.330

6. "Sighted C3H" mice--a tool for analysing the influence of vision on mouse behaviour?

Authors: Sabine M Hoelter; Claudia Dalke; Magdalena Kallnik; Lore Becker; Marion Horsch; Anja Schrewe; Jack Favor; Thomas Klopstock; Johannes Beckers; Boris Ivandic; Valérie Gailus-Durner; Helmut Fuchs; Martin Hrabé de Angelis; Jochen Graw; Wolfgang Wurst
Journal: Front Biosci Date: 2008-05-01

Review 7. Congenic mice: cutting tools for complex immune disorders.

Authors: Ute C Rogner; Philip Avner
Journal: Nat Rev Immunol Date: 2003-03 Impact factor: 53.106

8. Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum.

Authors: Christian Gieger; Ludwig Geistlinger; Elisabeth Altmaier; Martin Hrabé de Angelis; Florian Kronenberg; Thomas Meitinger; Hans-Werner Mewes; H-Erich Wichmann; Klaus M Weinberger; Jerzy Adamski; Thomas Illig; Karsten Suhre
Journal: PLoS Genet Date: 2008-11-28 Impact factor: 5.917

9. EuroPhenome and EMPReSS: online mouse phenotyping resource.

Authors: Ann-Marie Mallon; Andrew Blake; John M Hancock
Journal: Nucleic Acids Res Date: 2007-09-28 Impact factor: 16.971

10. ER stress-mediated apoptosis in a new mouse model of osteogenesis imperfecta.

Authors: Thomas S Lisse; Frank Thiele; Helmut Fuchs; Wolfgang Hans; Gerhard K H Przemeck; Koichiro Abe; Birgit Rathkolb; Leticia Quintanilla-Martinez; Gabriele Hoelzlwimmer; Miep Helfrich; Eckhard Wolf; Stuart H Ralston; Martin Hrabé de Angelis
Journal: PLoS Genet Date: 2008-02 Impact factor: 5.917

49 in total

Towards better mouse models: enhanced genotypes, systemic phenotyping and envirotype modelling.

1. Development of a human adaptive immune system in cord blood cell-transplanted mice.

2. FIMRe: Federation of International Mouse Resources: global networking of resource centers.

3. Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS.

4. Reconstruction of human mammary tissues in a mouse model.

5. Beethoven, a mouse model for dominant, progressive hearing loss DFNA36.

6. "Sighted C3H" mice--a tool for analysing the influence of vision on mouse behaviour?

Review 7. Congenic mice: cutting tools for complex immune disorders.

8. Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum.

9. EuroPhenome and EMPReSS: online mouse phenotyping resource.

10. ER stress-mediated apoptosis in a new mouse model of osteogenesis imperfecta.

1. Systematic phenotyping of mouse mutants.

Review 2. Colloquium papers: Numbering the hairs on our heads: the shared challenge and promise of phenomics.

Review 3. Mouse genetic and phenotypic resources for human genetics.

4. Model organisms: There's more to life than rats and flies.

Review 5. A review of standardized metabolic phenotyping of animal models.

Review 6. Mouse models in male fertility research.

7. The benefits and limitations of animal models for translational research in neurodegenerative diseases.

8. A hearing and vestibular phenotyping pipeline to identify mouse mutants with hearing impairment.

9. Epigenetic germline inheritance of diet-induced obesity and insulin resistance.

10. Altered sleep patterns and physiologic characteristics in spontaneous dwarf rats.