Literature DB >> 26974008

Epigenetic germline inheritance of diet-induced obesity and insulin resistance.

Peter Huypens1,2,3, Steffen Sass4, Moya Wu1,2, Daniela Dyckhoff1,2,3, Matthias Tschöp3,5,6, Fabian Theis4,7, Susan Marschall1,2, Martin Hrabě de Angelis1,2,3,8, Johannes Beckers1,2,3,8.   

Abstract

There is considerable controversy regarding epigenetic inheritance in mammalian gametes. Using in vitro fertilization to ensure exclusive inheritance via the gametes, we show that a parental high-fat diet renders offspring more susceptible to developing obesity and diabetes in a sex- and parent of origin-specific mode. The epigenetic inheritance of acquired metabolic disorders may contribute to the current obesity and diabetes pandemic.

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Year:  2016        PMID： 26974008     DOI： 10.1038/ng.3527

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  27 in total

Review 1.  Epigenetics and the origins of paternal effects.

Authors:  James P Curley; Rahia Mashoodh; Frances A Champagne
Journal:  Horm Behav       Date:  2010-07-08       Impact factor: 3.587

2.  Child to adult body mass index in the 1958 British birth cohort: associations with parental obesity.

Authors:  J K Lake; C Power; T J Cole
Journal:  Arch Dis Child       Date:  1997-11       Impact factor: 3.791

3.  Maternal obesity promotes a proinflammatory signature in rat uterus and blastocyst.

Authors:  Kartik Shankar; Ying Zhong; Ping Kang; Franchesca Lau; Michael L Blackburn; Jin-Ran Chen; Sarah J Borengasser; Martin J J Ronis; Thomas M Badger
Journal:  Endocrinology       Date:  2011-08-23       Impact factor: 4.736

4.  Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals.

Authors:  Upasna Sharma; Colin C Conine; Jeremy M Shea; Ana Boskovic; Alan G Derr; Xin Y Bing; Clemence Belleannee; Alper Kucukural; Ryan W Serra; Fengyun Sun; Lina Song; Benjamin R Carone; Emiliano P Ricci; Xin Z Li; Lucas Fauquier; Melissa J Moore; Robert Sullivan; Craig C Mello; Manuel Garber; Oliver J Rando
Journal:  Science       Date:  2015-12-31       Impact factor: 47.728

5.  Pre-gestational vs gestational exposure to maternal obesity differentially programs the offspring in mice.

Authors:  Isaac E Sasson; Alexa P Vitins; Monica A Mainigi; Kelle H Moley; Rebecca A Simmons
Journal:  Diabetologia       Date:  2014-12-11       Impact factor: 10.122

6.  Substantial intergenerational increases in body mass index are not explained by the fetal overnutrition hypothesis: the Cardiovascular Risk in Young Finns Study.

Authors:  Mika Kivimäki; Debbie A Lawlor; George Davey Smith; Marko Elovainio; Markus Jokela; Liisa Keltikangas-Järvinen; Jorma Sa Viikari; Olli T Raitakari
Journal:  Am J Clin Nutr       Date:  2007-11       Impact factor: 7.045

7.  Maternal obesity at conception programs obesity in the offspring.

Authors:  Kartik Shankar; Amanda Harrell; Xiaoli Liu; Janet M Gilchrist; Martin J J Ronis; Thomas M Badger
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2007-11-21       Impact factor: 3.619

8.  Richness of human gut microbiome correlates with metabolic markers.

Authors:  Emmanuelle Le Chatelier; Trine Nielsen; Junjie Qin; Edi Prifti; Falk Hildebrand; Gwen Falony; Mathieu Almeida; Manimozhiyan Arumugam; Jean-Michel Batto; Sean Kennedy; Pierre Leonard; Junhua Li; Kristoffer Burgdorf; Niels Grarup; Torben Jørgensen; Ivan Brandslund; Henrik Bjørn Nielsen; Agnieszka S Juncker; Marcelo Bertalan; Florence Levenez; Nicolas Pons; Simon Rasmussen; Shinichi Sunagawa; Julien Tap; Sebastian Tims; Erwin G Zoetendal; Søren Brunak; Karine Clément; Joël Doré; Michiel Kleerebezem; Karsten Kristiansen; Pierre Renault; Thomas Sicheritz-Ponten; Willem M de Vos; Jean-Daniel Zucker; Jeroen Raes; Torben Hansen; Peer Bork; Jun Wang; S Dusko Ehrlich; Oluf Pedersen
Journal:  Nature       Date:  2013-08-29       Impact factor: 49.962

9.  Maternal high-fat diet during gestation or suckling differentially affects offspring leptin sensitivity and obesity.

Authors:  Bo Sun; Ryan H Purcell; Chantelle E Terrillion; Jianqun Yan; Timothy H Moran; Kellie L K Tamashiro
Journal:  Diabetes       Date:  2012-06-29       Impact factor: 9.461

10.  RNA-mediated paternal heredity of diet-induced obesity and metabolic disorders.

Authors:  Valérie Grandjean; Sandra Fourré; Diana Andrea Fernandes De Abreu; Marie-Alix Derieppe; Jean-Jacques Remy; Minoo Rassoulzadegan
Journal:  Sci Rep       Date:  2015-12-14       Impact factor: 4.379
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  95 in total

Review 1.  Early life programming in mice by maternal overnutrition: mechanistic insights and interventional approaches.

Authors:  Lisa M Nicholas; Susan E Ozanne
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2019-04-15       Impact factor: 6.237

2.  Paternal and maternal preconception urinary phthalate metabolite concentrations and child behavior.

Authors:  Carmen Messerlian; David Bellinger; Lidia Mínguez-Alarcón; Megan E Romano; Jennifer B Ford; Paige L Williams; Antonia M Calafat; Russ Hauser; Joseph M Braun
Journal:  Environ Res       Date:  2017-07-21       Impact factor: 6.498

Review 3.  Paternal Nongenetic Intergenerational Transmission of Metabolic Disease Risk.

Authors:  Lei Su; Mary Elizabeth Patti
Journal:  Curr Diab Rep       Date:  2019-05-24       Impact factor: 4.810

Review 4.  Effect of Maternal Obesity on Foetal Growth and Metabolic Health of the Offspring.

Authors:  Claudio Maffeis; Anita Morandi
Journal:  Obes Facts       Date:  2017-04-07       Impact factor: 3.942

5.  Characterization of Metabolic Patterns in Mouse Oocytes during Meiotic Maturation.

Authors:  Ling Li; Shuai Zhu; Wenjie Shu; Yueshuai Guo; Yusheng Guan; Juan Zeng; Haichao Wang; Longsen Han; Jiaqi Zhang; Xiaohui Liu; Chunling Li; Xiaojing Hou; Min Gao; Juan Ge; Chao Ren; Hao Zhang; Tim Schedl; Xuejiang Guo; Minjian Chen; Qiang Wang
Journal:  Mol Cell       Date:  2020-10-16       Impact factor: 17.970

6.  Fat eggs shape offspring health.

Authors:  Erica D Watson; Joanna Rakoczy
Journal:  Nat Genet       Date:  2016-04-27       Impact factor: 38.330

Review 7.  Epigenetic Mechanisms of Transmission of Metabolic Disease across Generations.

Authors:  Vicencia Micheline Sales; Anne C Ferguson-Smith; Mary-Elizabeth Patti
Journal:  Cell Metab       Date:  2017-03-07       Impact factor: 27.287

8.  Adolescence and the next generation.

Authors:  George C Patton; Craig A Olsson; Vegard Skirbekk; Richard Saffery; Mary E Wlodek; Peter S Azzopardi; Marcin Stonawski; Bruce Rasmussen; Elizabeth Spry; Kate Francis; Zulfiqar A Bhutta; Nicholas J Kassebaum; Ali H Mokdad; Christopher J L Murray; Andrew M Prentice; Nicola Reavley; Peter Sheehan; Kim Sweeny; Russell M Viner; Susan M Sawyer
Journal:  Nature       Date:  2018-02-21       Impact factor: 49.962

Review 9.  Epigenetic inheritance of acquired traits through sperm RNAs and sperm RNA modifications.

Authors:  Qi Chen; Wei Yan; Enkui Duan
Journal:  Nat Rev Genet       Date:  2016-10-03       Impact factor: 53.242

Review 10.  Influence of maternal obesity, diet and exercise on epigenetic regulation of adipocytes.

Authors:  Archana Dhasarathy; James N Roemmich; Kate J Claycombe
Journal:  Mol Aspects Med       Date:  2016-11-04
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