Fei Wang1, Jessica H Kalmar2, Yong He3, Marcel Jackowski4, Lara G Chepenik2, Elliot Kale Edmiston5, Karen Tie2, Gaolang Gong6, Maulik P Shah2, Monique Jones5, Jodi Uderman5, R Todd Constable7, Hilary P Blumberg2. 1. Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut; Department of Psychiatry, Veterans Affairs, Connecticut Healthcare System, West Haven, Connecticut. Electronic address: fei.wang@yale.edu. 2. Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut; Department of Psychiatry, Veterans Affairs, Connecticut Healthcare System, West Haven, Connecticut. 3. State Key Laboratory of Cognitive Neuroscience, Beijing Normal University, Beijing, China; McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada. 4. Department of Diagnostic Radiology, Yale School of Medicine, New Haven, Connecticut; Institute of Mathematics and Statistics, University of São Paulo, São Paulo, Brazil. 5. Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut. 6. Biomedical Engineering Department, University of Alberta, Edmonton, Alberta, Canada. 7. Department of Diagnostic Radiology, Yale School of Medicine, New Haven, Connecticut.
Abstract
OBJECTIVE: Abnormalities in the morphology and function of two gray matter structures central to emotional processing, the perigenual anterior cingulate cortex (pACC) and amygdala, have consistently been reported in bipolar disorder (BD). Evidence implicates abnormalities in their connectivity in BD. This study investigates the potential disruptions in pACC-amygdala functional connectivity and associated abnormalities in white matter that provides structural connections between the two brain regions in BD. METHODS: Thirty-three individuals with BD and 31 healthy comparison subjects (HC) participated in a scanning session during which functional magnetic resonance imaging (fMRI) during processing of face stimuli and diffusion tensor imaging (DTI) were performed. The strength of pACC-amygdala functional connections was compared between BD and HC groups, and associations between these functional connectivity measures from the fMRI scans and regional fractional anisotropy (FA) from the DTI scans were assessed. RESULTS: Functional connectivity was decreased between the pACC and amygdala in the BD group compared with HC group, during the processing of fearful and happy faces (p < .005). Moreover, a significant positive association between pACC-amygdala functional coupling and FA in ventrofrontal white matter, including the region of the uncinate fasciculus, was identified (p < .005). CONCLUSION: This study provides evidence for abnormalities in pACC-amygdala functional connectivity during emotional processing in BD. The significant association between pACC-amygdala functional connectivity and the structural integrity of white matter that contains pACC-amygdala connections suggest that disruptions in white matter connectivity may contribute to disturbances in the coordinated responses of the pACC and amygdala during emotional processing in BD.
OBJECTIVE: Abnormalities in the morphology and function of two gray matter structures central to emotional processing, the perigenual anterior cingulate cortex (pACC) and amygdala, have consistently been reported in bipolar disorder (BD). Evidence implicates abnormalities in their connectivity in BD. This study investigates the potential disruptions in pACC-amygdala functional connectivity and associated abnormalities in white matter that provides structural connections between the two brain regions in BD. METHODS: Thirty-three individuals with BD and 31 healthy comparison subjects (HC) participated in a scanning session during which functional magnetic resonance imaging (fMRI) during processing of face stimuli and diffusion tensor imaging (DTI) were performed. The strength of pACC-amygdala functional connections was compared between BD and HC groups, and associations between these functional connectivity measures from the fMRI scans and regional fractional anisotropy (FA) from the DTI scans were assessed. RESULTS: Functional connectivity was decreased between the pACC and amygdala in the BD group compared with HC group, during the processing of fearful and happy faces (p < .005). Moreover, a significant positive association between pACC-amygdala functional coupling and FA in ventrofrontal white matter, including the region of the uncinate fasciculus, was identified (p < .005). CONCLUSION: This study provides evidence for abnormalities in pACC-amygdala functional connectivity during emotional processing in BD. The significant association between pACC-amygdala functional connectivity and the structural integrity of white matter that contains pACC-amygdala connections suggest that disruptions in white matter connectivity may contribute to disturbances in the coordinated responses of the pACC and amygdala during emotional processing in BD.
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