Literature DB >> 19422003

Design and synthesis of Trypanosoma brucei active 1-alkyloxy and 1-benzyloxyadamantano 2-guanylhydrazones.

Ioannis Papanastasiou1, Andrew Tsotinis, Grigoris Zoidis, Nicolas Kolocouris, S Radhika Prathalingam, John M Kelly.   

Abstract

Treating African trypanosomiasis: The synthesis and biological evaluation of novel 1-alkyloxy and 1-benzyloxyadamantano 2-guanylhydrazones, their 1-dioxa congeners and two 1-benzyladamantano 2-guanylhydrazones is reported. Preliminary structure-activity relationship data were elucidated and lead compounds suitable for further optimization were discovered.

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Year:  2009        PMID： 19422003     DOI： 10.1002/cmdc.200900019

Source DB:  PubMed          Journal:  ChemMedChem        ISSN： 1860-7179            Impact factor:   3.466


  5 in total

Review 1.  The lipophilic bullet hits the targets: medicinal chemistry of adamantane derivatives.

Authors:  Lukas Wanka; Khalid Iqbal; Peter R Schreiner
Journal:  Chem Rev       Date:  2013-02-25       Impact factor: 60.622

2.  Synthesis of benzopolycyclic cage amines: NMDA receptor antagonist, trypanocidal and antiviral activities.

Authors:  Eva Torres; María D Duque; Marta López-Querol; Martin C Taylor; Lieve Naesens; Chunlong Ma; Lawrence H Pinto; Francesc X Sureda; John M Kelly; Santiago Vázquez
Journal:  Bioorg Med Chem       Date:  2011-12-02       Impact factor: 3.641

3.  Probing the Effect of Halogen Substituents (Br, Cl, and F) on the Non-covalent Interactions in 1-(Adamantan-1-yl)-3-arylthiourea Derivatives: A Theoretical Study.

Authors:  Lamya H Al-Wahaibi; Divya Sri Grandhi; Samar S Tawfik; Nora H Al-Shaalan; Mohammed A Elmorsy; Ali A El-Emam; M Judith Percino; Subbiah Thamotharan
Journal:  ACS Omega       Date:  2021-02-10

4.  Searching for drug leads targeted to the hydrophobic cleft of dengue virus capsid protein.

Authors:  Liliane O Ortlieb; Ícaro P Caruso; Nathane C Mebus-Antunes; Andrea T Da Poian; Elaine da C Petronilho; José Daniel Figueroa-Villar; Claudia J Nascimento; Fabio C L Almeida
Journal:  J Enzyme Inhib Med Chem       Date:  2022-12       Impact factor: 5.051

5.  Synthesis and evaluation of novel 2,4-disubstituted arylthiazoles against T. brucei.

Authors:  Markos-Orestis Georgiadis; Violeta Kourbeli; Ioannis P Papanastasiou; Andrew Tsotinis; Martin C Taylor; John M Kelly
Journal:  RSC Med Chem       Date:  2019-12-19
  5 in total

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