Literature DB >> 19414567

Activity of SQ641, a capuramycin analog, in a murine model of tuberculosis.

Boris V Nikonenko1, Venkata M Reddy, Marina Protopopova, Elena Bogatcheva, Leo Einck, Carol A Nacy.   

Abstract

New delivery vehicles and routes of delivery were developed for the capuramycin analogue SQ641. While this compound has remarkable in vitro potency against Mycobacterium tuberculosis, it has low solubility in water and poor intracellular activity. We demonstrate here that SQ641 dissolved in the water-soluble vitamin E analogue alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) or incorporated into TPGS-micelles has significant activity in a mouse model of tuberculosis.

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Year:  2009        PMID： 19414567      PMCID： PMC2704676          DOI： 10.1128/AAC.00366-09

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  8 in total

1.  Drug therapy of experimental tuberculosis (TB): improved outcome by combining SQ109, a new diamine antibiotic, with existing TB drugs.

Authors:  Boris V Nikonenko; Marina Protopopova; Rowena Samala; Leo Einck; Carol A Nacy
Journal:  Antimicrob Agents Chemother       Date:  2007-01-22       Impact factor: 5.191

2.  In vitro antimycobacterial activities of capuramycin analogues.

Authors:  Venkata M Reddy; Leo Einck; Carol A Nacy
Journal:  Antimicrob Agents Chemother       Date:  2007-12-10       Impact factor: 5.191

3.  Rapid, simple in vivo screen for new drugs active against Mycobacterium tuberculosis.

Authors:  Boris V Nikonenko; Rowena Samala; Leo Einck; Carol A Nacy
Journal:  Antimicrob Agents Chemother       Date:  2004-12       Impact factor: 5.191

4.  Antagonism between isoniazid and the combination pyrazinamide-rifampin against tuberculosis infection in mice.

Authors:  J Grosset; C Truffot-Pernot; C Lacroix; B Ji
Journal:  Antimicrob Agents Chemother       Date:  1992-03       Impact factor: 5.191

Review 5.  Recent advances in antimicrobial nucleoside antibiotics targeting cell wall biosynthesis.

Authors:  Ken-ichi Kimura; Timothy D H Bugg
Journal:  Nat Prod Rep       Date:  2003-04       Impact factor: 13.423

6.  Activity of capuramycin analogues against Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium intracellulare in vitro and in vivo.

Authors:  Tetsufumi Koga; Takashi Fukuoka; Norio Doi; Tamako Harasaki; Harumi Inoue; Hitoshi Hotoda; Masayo Kakuta; Yasunori Muramatsu; Naotoshi Yamamura; Misa Hoshi; Takashi Hirota
Journal:  J Antimicrob Chemother       Date:  2004-09-03       Impact factor: 5.790

7.  Synthesis and antimycobacterial activity of capuramycin analogues. Part 1: substitution of the azepan-2-one moiety of capuramycin.

Authors:  Hitoshi Hotoda; Miyuki Furukawa; Makiko Daigo; Kazuhiro Murayama; Masakatsu Kaneko; Yasunori Muramatsu; Michiko Miyazawa Ishii; Shun-ichi Miyakoshi; Toshio Takatsu; Masatoshi Inukai; Masayo Kakuta; Tomomi Abe; Tamako Harasaki; Takashi Fukuoka; Yukio Utsui; Satoshi Ohya
Journal:  Bioorg Med Chem Lett       Date:  2003-09-01       Impact factor: 2.823

8.  Capuramycin, a new nucleoside antibiotic. Taxonomy, fermentation, isolation and characterization.

Authors:  H Yamaguchi; S Sato; S Yoshida; K Takada; M Itoh; H Seto; N Otake
Journal:  J Antibiot (Tokyo)       Date:  1986-08       Impact factor: 2.649
  8 in total
  25 in total

1.  Chemical modification of capuramycins to enhance antibacterial activity.

Authors:  Elena Bogatcheva; Tia Dubuisson; Marina Protopopova; Leo Einck; Carol A Nacy; Venkata M Reddy
Journal:  J Antimicrob Chemother       Date:  2010-12-23       Impact factor: 5.790

2.  Reconsidering some approved antimicrobial agents for tuberculosis.

Authors:  Lowell S Young
Journal:  Antimicrob Agents Chemother       Date:  2009-09-08       Impact factor: 5.191

3.  A biocatalytic approach to capuramycin analogues by exploiting a substrate permissive N-transacylase CapW.

Authors:  Xiaodong Liu; Yuanyuan Jin; Wenlong Cai; Keith D Green; Anwesha Goswami; Sylvie Garneau-Tsodikova; Koichi Nonaka; Satoshi Baba; Masanori Funabashi; Zhaoyong Yang; Steven G Van Lanen
Journal:  Org Biomol Chem       Date:  2016-04-06       Impact factor: 3.876

Review 4.  New agents for the treatment of drug-resistant Mycobacterium tuberculosis.

Authors:  Daniel T Hoagland; Jiuyu Liu; Robin B Lee; Richard E Lee
Journal:  Adv Drug Deliv Rev       Date:  2016-05-02       Impact factor: 15.470

Review 5.  Molecule Property Analyses of Active Compounds for Mycobacterium tuberculosis.

Authors:  Vadim Makarov; Elena Salina; Robert C Reynolds; Phyo Phyo Kyaw Zin; Sean Ekins
Journal:  J Med Chem       Date:  2020-04-20       Impact factor: 7.446

6.  The Biosynthesis of Capuramycin-type Antibiotics: IDENTIFICATION OF THE A-102395 BIOSYNTHETIC GENE CLUSTER, MECHANISM OF SELF-RESISTANCE, AND FORMATION OF URIDINE-5'-CARBOXAMIDE.

Authors:  Wenlong Cai; Anwesha Goswami; Zhaoyong Yang; Xiaodong Liu; Keith D Green; Sandra Barnard-Britson; Satoshi Baba; Masanori Funabashi; Koichi Nonaka; Manjula Sunkara; Andrew J Morris; Anatol P Spork; Christian Ducho; Sylvie Garneau-Tsodikova; Jon S Thorson; Steven G Van Lanen
Journal:  J Biol Chem       Date:  2015-04-08       Impact factor: 5.157

7.  DPAGT1 Inhibitors of Capuramycin Analogues and Their Antimigratory Activities of Solid Tumors.

Authors:  Katsuhiko Mitachi; Rita G Kansal; Kirk E Hevener; Cody D Gillman; Syed M Hussain; Hyun Gi Yun; Gustavo A Miranda-Carboni; Evan S Glazer; William M Clemons; Michio Kurosu
Journal:  J Med Chem       Date:  2020-09-18       Impact factor: 7.446

Review 8.  New drugs and regimens for treatment of TB.

Authors:  Eric Leibert; William N Rom
Journal:  Expert Rev Anti Infect Ther       Date:  2010-07       Impact factor: 5.091

9.  Functional and kinetic analysis of the phosphotransferase CapP conferring selective self-resistance to capuramycin antibiotics.

Authors:  Zhaoyong Yang; Masanori Funabashi; Koichi Nonaka; Masahiko Hosobuchi; Tomoyuki Shibata; Pallab Pahari; Steven G Van Lanen
Journal:  J Biol Chem       Date:  2010-03-04       Impact factor: 5.157

10.  Biosynthesis of a water-soluble lipid I analogue and a convenient assay for translocase I.

Authors:  Shajila Siricilla; Katsuhiko Mitachi; Karolina Skorupinska-Tudek; Ewa Swiezewska; Michio Kurosu
Journal:  Anal Biochem       Date:  2014-06-02       Impact factor: 3.365
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