Literature DB >> 12735700

Recent advances in antimicrobial nucleoside antibiotics targeting cell wall biosynthesis.

Ken-ichi Kimura1, Timothy D H Bugg.   

Abstract

The biosynthesis of peptidoglycan is essential for all bacteria and has no counterpart in eukaryotic cells. It is one of the prime targets for antibiotic chemotherapy, especially phospho-MurNAc-pentapeptide translocase (translocase I) is a fascinating target in which there is no commercial antibiotic. In this review we will describe three nucleoside translocase I inhibitors, mureidomycin, tunicamycin and liposidomycin.

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Year:  2003        PMID： 12735700     DOI： 10.1039/b202149h

Source DB:  PubMed          Journal:  Nat Prod Rep        ISSN： 0265-0568            Impact factor:   13.423


  46 in total

1.  Chemical modification of capuramycins to enhance antibacterial activity.

Authors:  Elena Bogatcheva; Tia Dubuisson; Marina Protopopova; Leo Einck; Carol A Nacy; Venkata M Reddy
Journal:  J Antimicrob Chemother       Date:  2010-12-23       Impact factor: 5.790

2.  Solid-phase synthesis and biological evaluation of a uridinyl branched peptide urea library.

Authors:  Dianqing Sun; Victoria Jones; Elizabeth I Carson; Robin E B Lee; Michael S Scherman; Michael R McNeil; Richard E Lee
Journal:  Bioorg Med Chem Lett       Date:  2007-10-04       Impact factor: 2.823

3.  In vitro antimycobacterial activities of capuramycin analogues.

Authors:  Venkata M Reddy; Leo Einck; Carol A Nacy
Journal:  Antimicrob Agents Chemother       Date:  2007-12-10       Impact factor: 5.191

4.  Selective catalytic hydrogenation of the N-acyl and uridyl double bonds in the tunicamycin family of protein N-glycosylation inhibitors.

Authors:  Neil Pj Price; Michael A Jackson; Karl E Vermillion; Judith A Blackburn; Jiakun Li; Biao Yu
Journal:  J Antibiot (Tokyo)       Date:  2017-11-01       Impact factor: 2.649

Review 5.  Molecule Property Analyses of Active Compounds for Mycobacterium tuberculosis.

Authors:  Vadim Makarov; Elena Salina; Robert C Reynolds; Phyo Phyo Kyaw Zin; Sean Ekins
Journal:  J Med Chem       Date:  2020-04-20       Impact factor: 7.446

Review 6.  Natural and engineered biosynthesis of nucleoside antibiotics in Actinomycetes.

Authors:  Wenqing Chen; Jianzhao Qi; Pan Wu; Dan Wan; Jin Liu; Xuan Feng; Zixin Deng
Journal:  J Ind Microbiol Biotechnol       Date:  2015-07-08       Impact factor: 3.346

7.  Identification and manipulation of the caprazamycin gene cluster lead to new simplified liponucleoside antibiotics and give insights into the biosynthetic pathway.

Authors:  Leonard Kaysser; Liane Lutsch; Stefanie Siebenberg; Emmanuel Wemakor; Bernd Kammerer; Bertolt Gust
Journal:  J Biol Chem       Date:  2009-04-07       Impact factor: 5.157

8.  Methods for direct alkene diamination, new & old.

Authors:  Sam de Jong; Daniel G Nosal; Duncan J Wardrop
Journal:  Tetrahedron       Date:  2012-03-21       Impact factor: 2.457

9.  Nucleoside triphosphate mimicry: a sugar triazolyl nucleoside as an ATP-competitive inhibitor of B. anthracis pantothenate kinase.

Authors:  Andrew S Rowan; Nathan I Nicely; Nicola Cochrane; Wjatschesslaw A Wlassoff; Al Claiborne; Chris J Hamilton
Journal:  Org Biomol Chem       Date:  2009-07-27       Impact factor: 3.876

10.  Concise synthesis of capuramycin.

Authors:  Michio Kurosu; Kai Li; Dean C Crick
Journal:  Org Lett       Date:  2009-06-04       Impact factor: 6.005
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