AIMS: Endothelial lipase (LIPG) is implicated in the metabolism of high-density lipoprotein cholesterol (HDL-C). Small studies in selected populations have reported higher HDL-C levels among carriers of the common T111I variant in LIPG, but whether this variant is associated with plasma lipids and risk of coronary heart disease (CHD) in the general population is unclear. The objective of this study was to address the associations of the T111I variant with plasma lipids and risk of CHD in three independent prospective studies of generally healthy men and women. METHODS AND RESULTS: The T111I variant was genotyped in case-control studies of CHD nested within the Diet, Cancer, and Health study with 998 cases, Nurses' Health Study with 241 cases, and Health Professionals Follow-up Study with 262 cases. The minor allele frequency in the combined pool of controls was 0.29. The T111I variant was not associated with HDL-C or any other lipid and lipoprotein measures. Compared with wildtype homozygotes, the pooled estimate for risk of CHD was 0.95 (0.85-1.06) per T111I allele. CONCLUSION: Our analysis among healthy Caucasian men and women from three independent studies does not support an association between the T111I variant and HDL-C, other plasma lipids, or risk of CHD.
AIMS: Endothelial lipase (LIPG) is implicated in the metabolism of high-density lipoprotein cholesterol (HDL-C). Small studies in selected populations have reported higher HDL-C levels among carriers of the common T111I variant in LIPG, but whether this variant is associated with plasma lipids and risk of coronary heart disease (CHD) in the general population is unclear. The objective of this study was to address the associations of the T111I variant with plasma lipids and risk of CHD in three independent prospective studies of generally healthy men and women. METHODS AND RESULTS: The T111I variant was genotyped in case-control studies of CHD nested within the Diet, Cancer, and Health study with 998 cases, Nurses' Health Study with 241 cases, and Health Professionals Follow-up Study with 262 cases. The minor allele frequency in the combined pool of controls was 0.29. The T111I variant was not associated with HDL-C or any other lipid and lipoprotein measures. Compared with wildtype homozygotes, the pooled estimate for risk of CHD was 0.95 (0.85-1.06) per T111I allele. CONCLUSION: Our analysis among healthy Caucasian men and women from three independent studies does not support an association between the T111I variant and HDL-C, other plasma lipids, or risk of CHD.
Authors: Jennifer K Pai; Gary C Curhan; Carolyn C Cannuscio; Nader Rifai; Paul M Ridker; Eric B Rimm Journal: Clin Chem Date: 2002-10 Impact factor: 8.327
Authors: Ke Ma; Mehmet Cilingiroglu; James D Otvos; Christie M Ballantyne; Ali J Marian; Lawrence Chan Journal: Proc Natl Acad Sci U S A Date: 2003-02-24 Impact factor: 11.205
Authors: Andrew C Edmondson; Robert J Brown; Sekar Kathiresan; L Adrienne Cupples; Serkalem Demissie; Alisa Knodle Manning; Majken K Jensen; Eric B Rimm; Jian Wang; Amrith Rodrigues; Vaneeta Bamba; Sumeet A Khetarpal; Megan L Wolfe; Stephanie Derohannessian; Mingyao Li; Muredach P Reilly; Jens Aberle; David Evans; Robert A Hegele; Daniel J Rader Journal: J Clin Invest Date: 2009-03-16 Impact factor: 14.808
Authors: Uli C Broedl; Cyrille Maugeais; John S Millar; Weijun Jin; Ryan E Moore; Ilia V Fuki; Dawn Marchadier; Jane M Glick; Daniel J Rader Journal: Circ Res Date: 2004-04-29 Impact factor: 17.367
Authors: Albert Marni Joensen; Majken K Jensen; Kim Overvad; Claus Dethlefsen; Erik Schmidt; Lars Rasmussen; Anne Tjønneland; Søren Johnsen Journal: J Clin Epidemiol Date: 2008-08-22 Impact factor: 6.437
Authors: Amy Halverstadt; Dana A Phares; Robert E Ferrell; Kenneth R Wilund; Andrew P Goldberg; James M Hagberg Journal: Metabolism Date: 2003-11 Impact factor: 8.694
Authors: Ulla Vogel; Majken K Jensen; Karen Margrete Due; Eric B Rimm; Håkan Wallin; Michael R S Nielsen; Anne-Pernille T Pedersen; Anne Tjønneland; Kim Overvad Journal: Atherosclerosis Date: 2011-06-17 Impact factor: 5.162
Authors: Julian C van Capelleveen; Andrea E Bochem; M Mahdi Motazacker; G Kees Hovingh; John J P Kastelein Journal: Curr Atheroscler Rep Date: 2013-06 Impact factor: 5.113
Authors: Hamid Razzaghi; Anna Tempczyk-Russell; Kurt Haubold; Stephanie A Santorico; Touraj Shokati; Uwe Christians; Mair E A Churchill Journal: PLoS One Date: 2013-03-25 Impact factor: 3.240