Ding Huang1, Xiang Xie, Yi-Tong Ma, Ying Huang, Xiang Ma. 1. Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical University , Xinjiang, People's Republic of China .
Abstract
OBJECTIVE: To explore the relationship between the endothelial lipase (EL) gene promoter -384A/C polymorphism and acute coronary syndrome (ACS) and lipid status in elderly Uygur patients in Xinjiang. METHODS: The polymerase chain reaction-restriction fragment length polymorphism method was used to detect the EL gene promoter -384A/C genotype in 341 cases of elderly patients with ACS and 380 healthy subjects. RESULTS: In an elderly Chinese Han population, the EL-384A/C genotype and allele frequency distribution were significantly different between the ACS group and the control group (p<0.05); the frequency of the CC genotype in the ACS group was significantly higher than that in the control group (p<0.05). After adjusting for gender, age, diabetes, hypertension, smoking, hyperlipidemia, and other cardiovascular risk factors, the difference remains statistically significant (p<0.05). In the ACS group, C allele carriers had significantly higher serum triglycerides, total cholesterol, and low-density lipoprotein cholesterol concentrations compared to AA genotypes (all p<0.05). CONCLUSION: EL-384A/C polymorphism was significantly associated with the ACS and lipids profile in an elderly Uygur population in Xinjiang.
OBJECTIVE: To explore the relationship between the endothelial lipase (EL) gene promoter -384A/C polymorphism and acute coronary syndrome (ACS) and lipid status in elderly Uygur patients in Xinjiang. METHODS: The polymerase chain reaction-restriction fragment length polymorphism method was used to detect the EL gene promoter -384A/C genotype in 341 cases of elderly patients with ACS and 380 healthy subjects. RESULTS: In an elderly Chinese Han population, the EL-384A/C genotype and allele frequency distribution were significantly different between the ACS group and the control group (p<0.05); the frequency of the CC genotype in the ACS group was significantly higher than that in the control group (p<0.05). After adjusting for gender, age, diabetes, hypertension, smoking, hyperlipidemia, and other cardiovascular risk factors, the difference remains statistically significant (p<0.05). In the ACS group, C allele carriers had significantly higher serum triglycerides, total cholesterol, and low-density lipoprotein cholesterol concentrations compared to AA genotypes (all p<0.05). CONCLUSION:EL-384A/C polymorphism was significantly associated with the ACS and lipids profile in an elderly Uygur population in Xinjiang.
Authors: Carolyn M Hutter; Melissa A Austin; Federico M Farin; Hannah-Malia Viernes; Karen L Edwards; Donna L Leonetti; Marguerite J McNeely; Wilfred Y Fujimoto Journal: Atherosclerosis Date: 2005-07-14 Impact factor: 5.162
Authors: Andrew S deLemos; Megan L Wolfe; Christopher J Long; Rasheeta Sivapackianathan; Daniel J Rader Journal: Circulation Date: 2002-09-10 Impact factor: 29.690
Authors: Majken K Jensen; Eric B Rimm; Kenneth J Mukamal; Andrew C Edmondson; Daniel J Rader; Ulla Vogel; Anne Tjønneland; Thorkild I A Sørensen; Erik B Schmidt; Kim Overvad Journal: Eur Heart J Date: 2009-05-02 Impact factor: 29.983