PRIMARY OBJECTIVE: The present study used fMRI (functional magnetic resonance imaging) to objectively assess cognitive fatigue in persons with traumatic brain injury (TBI). It was hypothesized that while performing a cognitive task, TBI participants would show increased brain activity over time, indicative of increased cerebral 'effort' which might manifest as the subjective feeling of cognitive fatigue. METHODS AND PROCEDURES: Functional MRI was used to track brain activity across time while 11 TBI patients with moderate-severe injury and 11 age-matched healthy controls (HCs) performed a modified Symbol Digit Modalities Task (mSDMT). Cognitive fatigue was operationally defined as a relative increase in cerebral activation across time compared to that seen in HCs. ROIs were derived from the Chauduri and Behan model of cognitive fatigue. MAIN OUTCOMES AND RESULTS: While performing the mSDMT, participants with a TBI showed increased activity, while HCs subsequently showed decreased activity in several regions including the middle frontal gyrus, superior parietal cortex, basal ganglia and anterior cingulate. CONCLUSIONS: Increased brain activity exhibited by participants with a TBI might represent increased cerebral effort which may be manifested as cognitive fatigue. Functional MRI appears to be a potentially useful tool for understanding the neural mechanisms associated with cognitive fatigue in TBI.
PRIMARY OBJECTIVE: The present study used fMRI (functional magnetic resonance imaging) to objectively assess cognitive fatigue in persons with traumatic brain injury (TBI). It was hypothesized that while performing a cognitive task, TBI participants would show increased brain activity over time, indicative of increased cerebral 'effort' which might manifest as the subjective feeling of cognitive fatigue. METHODS AND PROCEDURES: Functional MRI was used to track brain activity across time while 11 TBI patients with moderate-severe injury and 11 age-matched healthy controls (HCs) performed a modified Symbol Digit Modalities Task (mSDMT). Cognitive fatigue was operationally defined as a relative increase in cerebral activation across time compared to that seen in HCs. ROIs were derived from the Chauduri and Behan model of cognitive fatigue. MAIN OUTCOMES AND RESULTS: While performing the mSDMT, participants with a TBI showed increased activity, while HCs subsequently showed decreased activity in several regions including the middle frontal gyrus, superior parietal cortex, basal ganglia and anterior cingulate. CONCLUSIONS: Increased brain activity exhibited by participants with a TBI might represent increased cerebral effort which may be manifested as cognitive fatigue. Functional MRI appears to be a potentially useful tool for understanding the neural mechanisms associated with cognitive fatigue in TBI.
Authors: John D Medaglia; Kathy S Chiou; Julia Slocomb; Neal M Fitzpatrick; Britney M Wardecker; Deepa Ramanathan; Jeffrey Vesek; David C Good; Frank G Hillary Journal: Hum Brain Mapp Date: 2011-05-17 Impact factor: 5.038
Authors: Jennifer L McGuire; Erica A K DePasquale; Miki Watanabe; Fatima Anwar; Laura B Ngwenya; Gowtham Atluri; Lindsey E Romick-Rosendale; Robert E McCullumsmith; Nathan K Evanson Journal: Mol Neurobiol Date: 2018-08-01 Impact factor: 5.590
Authors: Meghan E Heffernan; Wei Huang; Kenneth M Sicard; Bernt T Bratane; Elif M Sikoglu; Nanyin Zhang; Marc Fisher; Jean A King Journal: J Neurotrauma Date: 2013-06-05 Impact factor: 5.269
Authors: Kristine M Knutson; Olga Dal Monte; Vanessa Raymont; Eric M Wassermann; Frank Krueger; Jordan Grafman Journal: Hum Brain Mapp Date: 2013-02-13 Impact factor: 5.038