Ziyan Wu1, Catherine A Mazzola2, Lori Catania3, Oyindamola Owoeye4, Chang Yaramothu4, Tara Alvarez4, Yu Gao5, Xiaobo Li1,4. 1. Department of Electrical and Computer Engineering, New Jersey Institute of Technology, Newark, NJ, USA. 2. New Jersey Pediatric Neuroscience Institute, Morristown, NJ, USA. 3. North Jersey Neurodevelopmental Center, North Haledon, NJ, USA. 4. Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, USA. 5. Department of Psychology, Brooklyn College and the Graduate Center of the City University of New York, Brooklyn, NY, USA.
Abstract
AIMS: This study aimed at understanding the neurobiological mechanisms associated with inattention induced by traumatic brain injury (TBI). To eliminate the potential confounding caused by the heterogeneity of TBI, we focused on young adults postsports-related concussion (SRC). METHODS: Functional near-infrared spectroscopy (fNIRS) data were collected from 27 young adults post-SRC and 27 group-matched normal controls (NCs), while performing a visual sustained attention task. Task responsive cortical activation maps and pairwise functional connectivity among six regions of interest were constructed for each subject. Correlations among the brain imaging measures and clinical measures of attention were calculated in each group. RESULTS: Compared to the NCs, the SRC group showed significantly increased brain activation in left middle frontal gyrus (MFG) and increased functional connectivity between right inferior occipital cortex (IOC) bilateral calcarine gyri (CG). The left MFG activation magnitude was significantly negatively correlated with the hyperactive/impulsive symptom severity measure in the NCs, but not in the patients. The right hemisphere CG-IOC functional connectivity showed a significant positive correlation with the hyperactive/impulsive symptom severity measure in patients, but not in NCs. CONCLUSION: The current data suggest that abnormal left MFG activation and hyper-communications between right IOC and bilateral CG during visual attention processing may significantly contribute to behavioral manifestations of attention deficits in patients with TBI.
AIMS: This study aimed at understanding the neurobiological mechanisms associated with inattention induced by traumatic brain injury (TBI). To eliminate the potential confounding caused by the heterogeneity of TBI, we focused on young adults postsports-related concussion (SRC). METHODS: Functional near-infrared spectroscopy (fNIRS) data were collected from 27 young adults post-SRC and 27 group-matched normal controls (NCs), while performing a visual sustained attention task. Task responsive cortical activation maps and pairwise functional connectivity among six regions of interest were constructed for each subject. Correlations among the brain imaging measures and clinical measures of attention were calculated in each group. RESULTS: Compared to the NCs, the SRC group showed significantly increased brain activation in left middle frontal gyrus (MFG) and increased functional connectivity between right inferior occipital cortex (IOC) bilateral calcarine gyri (CG). The left MFG activation magnitude was significantly negatively correlated with the hyperactive/impulsive symptom severity measure in the NCs, but not in the patients. The right hemisphere CG-IOC functional connectivity showed a significant positive correlation with the hyperactive/impulsive symptom severity measure in patients, but not in NCs. CONCLUSION: The current data suggest that abnormal left MFG activation and hyper-communications between right IOC and bilateral CG during visual attention processing may significantly contribute to behavioral manifestations of attention deficits in patients with TBI.
Authors: Jeffrey E Max; Russell J Schachar; Harvey S Levin; Linda Ewing-Cobbs; Sandra B Chapman; Maureen Dennis; Ann Saunders; Julie Landis Journal: J Am Acad Child Adolesc Psychiatry Date: 2005-10 Impact factor: 8.829
Authors: Jeffrey E Max; Russell J Schachar; Harvey S Levin; Linda Ewing-Cobbs; Sandra B Chapman; Maureen Dennis; Ann Saunders; Julie Landis Journal: J Am Acad Child Adolesc Psychiatry Date: 2005-10 Impact factor: 8.829
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