Literature DB >> 19407370

Structure of pig heart citrate synthase at 1.78 A resolution.

Steven B Larson1, John S Day, Chieugiang Nguyen, Robert Cudney, Alexander McPherson.   

Abstract

Pig heart citrate synthase was crystallized from a small-molecule cocktail containing cystamine dihydrochloride, aspartame and benzamidine hydrochloride. The structure was refined to an R factor of 0.179 (R(free) = 0.222) using synchrotron data to a resolution of 1.78 A. The model includes the full-length protein, a chloride ion, a sulfate ion, 305 water molecules and an unexpected moiety attached through a disulfide linkage to Cys184, which was modeled as a half-cystamine molecule generated by disulfide exchange with the cystamine in the small-molecule cocktail.

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Year:  2009        PMID： 19407370      PMCID： PMC2675578          DOI： 10.1107/S1744309109008343

Source DB:  PubMed          Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun        ISSN： 1744-3091


  10 in total

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  8 in total

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