| Literature DB >> 194012 |
J A Cohn, A P Alvares, A Kappas.
Abstract
The difference spectra of the carbon monoxide-complex of dithionite-reduced rat brain microsomes, compared with both reduced microsomes, alone, and the carbon monoxide-complex of oxidized microsomes, indicate the presence of small amounts of cytochrome P-450 in brain. As in liver, cytochrome P-450 in brain is degraded in vitro to its inactive form, cytochrome P-420 by methylmercury chloride. Aryl hydrocarbon hydroxylase activity is also present in rat brain microsomes and, at lower specific activity, in brain homogenates. This carcinogen metabolizing activity is increased four-fold in rats pretreated with 3-methylcholanthrene.Entities:
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Year: 1977 PMID： 194012 PMCID： PMC2180688 DOI： 10.1084/jem.145.6.1607
Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307