Literature DB >> 7418834

Comparison of dihydrodiazepam enantiomers: metabolism, serum binding and brain receptor binding.

Z Tegyey, G Maksay, J Kardos, L Otvös.   

Abstract

Dihydrodiazepam is a diazepam prodrug, as shown by its in vitro metabolism by rat and mouse liver and brain microsomal fractions, and its displacing activity on brain diazepam binding. The mechanism of bioactivation is discussed. Stereoselectivity of metabolism and of binding to specific benzodiazepine binding sites in brain synpatosomes and serum albumin were studied.

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Year:  1980        PMID： 7418834     DOI： 10.1007/bf01965950

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  12 in total

1.  Benzodiazepine receptors in rat brain.

Authors:  R F Squires; C Brastrup
Journal:  Nature       Date:  1977-04-21       Impact factor: 49.962

2.  Metabolism of levorotary 4,5-dihydrodiazepam in the rat.

Authors:  L Otvös; Z Tegyey; L Vereczkey; M Ledniczky; J Tamás; E Pálosi; L Szporny
Journal:  Drug Metab Dispos       Date:  1978 May-Jun       Impact factor: 3.922

3.  Stereostructure-activity relationships for oxazepam hemisuccinate. Effects on central nervous system.

Authors:  L de Angelis; M Predominato; R Vertua
Journal:  Arzneimittelforschung       Date:  1972-08

4.  [Pharmacological study of the optically active modifications of 1,3,4,5-tetrahydro-1,4-benzodiazepine-2-one].

Authors:  E Pálosi; L Urögdi; J Röhricht; L Szporny; L Kisfaludy
Journal:  Acta Pharm Hung       Date:  1973-09

5.  Analytical and pharmacokinetic studies on the optic isomers of oxazepam succinate half-ester.

Authors:  E Mussini; F Marcucci; R Fanelli; A Guaitani; S Garattini
Journal:  Biochem Pharmacol       Date:  1972-01       Impact factor: 5.858

6.  Microsomal oxidase. IV. Properties of a mixed-function amine oxidase isolated from pig liver microsomes.

Authors:  D M Ziegler; C H Mitchell
Journal:  Arch Biochem Biophys       Date:  1972-05       Impact factor: 4.013

7.  Stereospecific benzodiazepine receptor binding by the enantiomers of oxazepam sodium hemisuccinate.

Authors:  J L Waddington; F Owen
Journal:  Neuropharmacology       Date:  1978-03       Impact factor: 5.250

8.  Metabolism and anticonvulsant activity of deuterated N-demethyldiazepam.

Authors:  F Marcucci; E Mussini; P Martelli; A Guaitani; S Garattini
Journal:  J Pharm Sci       Date:  1973-11       Impact factor: 3.534

9.  Examination of the metabolism in vitro of parathion (diethyl p-nitrophenyl phosphorothionate) by rat lung and brain.

Authors:  B J Norman; R A Neal
Journal:  Biochem Pharmacol       Date:  1976-01       Impact factor: 5.858

10.  On the occurrence of cytochrome P-450 and aryl hydrocarbon hydroxylase activity in rat brain.

Authors:  J A Cohn; A P Alvares; A Kappas
Journal:  J Exp Med       Date:  1977-06-01       Impact factor: 14.307
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  1 in total

1.  Stereoselective binding of 4,5-dihydrodiazepam to human serum albumin.

Authors:  I Fitos; M Simonyi
Journal:  Experientia       Date:  1983-06-15
  1 in total

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