| Literature DB >> 19398771 |
S D Berry1, S R Davis, E M Beattie, N L Thomas, A K Burrett, H E Ward, A M Stanfield, M Biswas, A E Ankersmit-Udy, P E Oxley, J L Barnett, J F Pearson, Y van der Does, A H K Macgibbon, R J Spelman, K Lehnert, R G Snell.
Abstract
beta-Carotene biochemistry is a fundamental process in mammalian biology. Aberrations either through malnutrition or potentially through genetic variation may lead to vitamin A deficiency, which is a substantial public health burden. In addition, understanding the genetic regulation of this process may enable bovine improvement. While many bovine QTL have been reported, few of the causative genes and mutations have been identified. We discovered a QTL for milk beta-carotene and subsequently identified a premature stop codon in bovine beta-carotene oxygenase 2 (BCO2), which also affects serum beta-carotene content. The BCO2 enzyme is thereby identified as a key regulator of beta-carotene metabolism.Entities:
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Year: 2009 PMID： 19398771 PMCID： PMC2710170 DOI： 10.1534/genetics.109.101741
Source DB: PubMed Journal: Genetics ISSN： 0016-6731 Impact factor: 4.562