Literature DB >> 19393580

Neurotensin signaling induces intracellular alkalinization and interleukin-8 expression in human pancreatic cancer cells.

Ulrike Olszewski1, Gerhard Hamilton.   

Abstract

Pancreatic adenocarcinomas express neurotensin receptors in up to 90% of cases, however, their role in tumor biology and as a drug target is not clear. In the present study, a stable neurotensin (NT) analog induced intracellular calcium release and intracellular alkalinization in BxPC-3 and PANC-1 pancreatic cancer cells that was abolished by inhibitors of NT receptor (NTR) and sodium-proton exchanger 1 (NHE1), amiloride and SR 142948, respectively. Activation of NHE1 involved increased phosphorylation of dimethylfumarate-sensitive mitogen- and stress-activated kinase 1/2 (MSK1/2). NTR signaling appears to promote a metastatic phenotype in pancreatic cancer cells by induction of localized extracellular acidification in normoxic cells, preceeding acidosis induced by hypoxia and switch to glycolysis in addition to increased expression of interleukin-8 (IL-8).

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Year:  2009        PMID： 19393580      PMCID： PMC5527856          DOI： 10.1016/j.molonc.2009.01.006

Source DB:  PubMed          Journal:  Mol Oncol        ISSN： 1574-7891            Impact factor:   6.603


  56 in total

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Authors:  Patrick Kitabgi
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Review 2.  Structural and functional analysis of the Na+/H+ exchanger.

Authors:  Emily R Slepkov; Jan K Rainey; Brian D Sykes; Larry Fliegel
Journal:  Biochem J       Date:  2007-02-01       Impact factor: 3.857

3.  Examination of the role for Ca2+ in regulation and phosphorylation of the Na+/H+ antiporter NHE1 via mitogen and hypertonic stimulation.

Authors:  R L McSwine; J Li; M L Villereal
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4.  MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts.

Authors:  Giselle R Wiggin; Ana Soloaga; Julia M Foster; Victoria Murray-Tait; Philip Cohen; J Simon C Arthur
Journal:  Mol Cell Biol       Date:  2002-04       Impact factor: 4.272

Review 5.  Autocrine and paracrine signaling through neuropeptide receptors in human cancer.

Authors:  L E Heasley
Journal:  Oncogene       Date:  2001-03-26       Impact factor: 9.867

Review 6.  Neurotensin and neurotensin receptors.

Authors:  J P Vincent; J Mazella; P Kitabgi
Journal:  Trends Pharmacol Sci       Date:  1999-07       Impact factor: 14.819

7.  Cytosolic alkalinization increases stress-activated protein kinase/c-Jun NH2-terminal kinase (SAPK/JNK) activity and p38 mitogen-activated protein kinase activity by a calcium-independent mechanism.

Authors:  L D Shrode; E A Rubie; J R Woodgett; S Grinstein
Journal:  J Biol Chem       Date:  1997-05-23       Impact factor: 5.157

8.  The p42/p44 mitogen-activated protein kinase cascade is determinant in mediating activation of the Na+/H+ exchanger (NHE1 isoform) in response to growth factors.

Authors:  L Bianchini; G L'Allemain; J Pouysségur
Journal:  J Biol Chem       Date:  1997-01-03       Impact factor: 5.157

9.  MSK1 is required for CREB phosphorylation in response to mitogens in mouse embryonic stem cells.

Authors:  J S Arthur; P Cohen
Journal:  FEBS Lett       Date:  2000-09-29       Impact factor: 4.124

10.  Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB.

Authors:  M Deak; A D Clifton; L M Lucocq; D R Alessi
Journal:  EMBO J       Date:  1998-08-03       Impact factor: 11.598
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  12 in total

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2.  The volume-regulated anion channel (LRRC8) in nodose neurons is sensitive to acidic pH.

Authors:  Runping Wang; Yongjun Lu; Susheel Gunasekar; Yanhui Zhang; Christopher J Benson; Mark W Chapleau; Rajan Sah; François M Abboud
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3.  Neurotensin signaling induces intracellular alkalinization and interleukin-8 expression in human pancreatic cancer cells.

Authors:  Ulrike Olszewski; Gerhard Hamilton
Journal:  Mol Oncol       Date:  2009-02-03       Impact factor: 6.603

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Journal:  PLoS One       Date:  2013-02-13       Impact factor: 3.240

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Authors:  Kristin M Müller; Ingun H Tveteraas; Monica Aasrum; John Ødegård; Mona Dawood; Olav Dajani; Thoralf Christoffersen; Dagny L Sandnes
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6.  Neurotensin receptors in pancreatic ductal carcinomas.

Authors:  Meike Körner; Beatrice Waser; Oliver Strobel; Markus Büchler; Jean Claude Reubi
Journal:  EJNMMI Res       Date:  2015-03-24       Impact factor: 3.138

Review 7.  New extracellular factors in glioblastoma multiforme development: neurotensin, growth differentiation factor-15, sphingosine-1-phosphate and cytomegalovirus infection.

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Journal:  Oncotarget       Date:  2018-01-09

Review 8.  (Patho-)Physiology of Na+/H+ Exchangers (NHEs) in the Digestive System.

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10.  Neurotensin promotes the progression of malignant glioma through NTSR1 and impacts the prognosis of glioma patients.

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