Literature DB >> 10390649

Neurotensin and neurotensin receptors.

J P Vincent1, J Mazella, P Kitabgi.   

Abstract

Neurotensin is a brain and gastrointestinal peptide that fulfils many central and peripheral functions through its interaction with specific receptors. Three subtypes of neurotensin receptors have been cloned. Two of them belong to the family of G protein-coupled receptors, whereas the third one is an entirely new type of neuropeptide receptor and is identical to gp95/sortilin, a 100 kDa-protein with a single transmembrane domain. In this review, the present knowledge regarding the molecular and pharmacological properties of the three cloned neurotensin receptors is summarized and the relationship between these receptors and the known pharmacological effects of neurotensin is discussed.

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Year:  1999        PMID： 10390649     DOI： 10.1016/s0165-6147(99)01357-7

Source DB:  PubMed          Journal:  Trends Pharmacol Sci        ISSN： 0165-6147            Impact factor:   14.819


  116 in total

1.  Genome-wide gene expression profiles of the developing mouse hippocampus.

Authors:  M Mody; Y Cao; Z Cui; K Y Tay; A Shyong; E Shimizu; K Pham; P Schultz; D Welsh; J Z Tsien
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-03       Impact factor: 11.205

2.  Reactivity of peptidyl-tyrosine to hydroxylation and cross-linking.

Authors:  L A Burzio; J H Waite
Journal:  Protein Sci       Date:  2001-04       Impact factor: 6.725

3.  Modulation of the interaction between neurotensin receptor NTS1 and Gq protein by lipid.

Authors:  Sayaka Inagaki; Rodolfo Ghirlando; Jim F White; Jelena Gvozdenovic-Jeremic; John K Northup; Reinhard Grisshammer
Journal:  J Mol Biol       Date:  2012-01-27       Impact factor: 5.469

4.  Activation of matrix metalloproteinase-9 (MMP-9) by neurotensin promotes cell invasion and migration through ERK pathway in gastric cancer.

Authors:  Hafeza Akter; Min Park; Oh-Seung Kwon; Eun Joo Song; Won-Sang Park; Min-Jung Kang
Journal:  Tumour Biol       Date:  2015-02-28

5.  Production and Characterization of a Novel Monoclonal Antibody Against Human Sortilin.

Authors:  Fatemeh Ghaemimanesh; Ali Ahmad Bayat; Sepideh Babaei; Gholamreza Ahmadian; Amir-Hassan Zarnani; Mehrdad Behmanesh; Mahmood Jeddi-Tehrani; Hodjattallah Rabbani
Journal:  Monoclon Antib Immunodiagn Immunother       Date:  2015-12

6.  Increased ethanol consumption and preference in mice lacking neurotensin receptor type 2.

Authors:  Moonnoh R Lee; David J Hinton; Sencan S Unal; Elliott Richelson; Doo-Sup Choi
Journal:  Alcohol Clin Exp Res       Date:  2010-10-06       Impact factor: 3.455

7.  Large-scale expression and purification of a G-protein-coupled receptor for structure determination -- an overview.

Authors:  Reinhard Grisshammer; Jim F White; Loc B Trinh; Joseph Shiloach
Journal:  J Struct Funct Genomics       Date:  2005

8.  Glycosylated neurotensin analogues exhibit sub-picomolar anticonvulsant potency in a pharmacoresistant model of epilepsy.

Authors:  Hee-Kyoung Lee; Liuyin Zhang; Misty D Smith; H Steve White; Grzegorz Bulaj
Journal:  ChemMedChem       Date:  2009-03       Impact factor: 3.466

9.  In Search of the Optimal Macrocyclization Site for Neurotensin.

Authors:  Marc Sousbie; Élie Besserer-Offroy; Rebecca L Brouillette; Jean-Michel Longpré; Richard Leduc; Philippe Sarret; Éric Marsault
Journal:  ACS Med Chem Lett       Date:  2018-01-29       Impact factor: 4.345

10.  Neurotensin stimulates sortilin and mTOR in human microglia inhibitable by methoxyluteolin, a potential therapeutic target for autism.

Authors:  Arti B Patel; Irene Tsilioni; Susan E Leeman; Theoharis C Theoharides
Journal:  Proc Natl Acad Sci U S A       Date:  2016-09-23       Impact factor: 11.205
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