| Literature DB >> 19391593 |
Akin H Davulcu1, Douglas D McLeod, Jun Li, Kishta Katipally, Adam Littke, Wendel Doubleday, Zhongmin Xu, Cary W McConlogue, Chiajen J Lai, Margaret Gleeson, Mark Schwinden, Rodney L Parsons.
Abstract
BMS-317180 (1) is a potent, orally active agonist of the human growth hormone secretagogue (GHS) receptor. This manuscript details the process research and development efforts that enabled the synthesis of the phosphate salt of 1 on a multi-kilogram scale. Key considerations in the development of this process focused on safe execution and the requirement for telescoped synthetic transformations (i.e., without isolation of intermediate products) to contend with a lack of suitably crystalline products.Entities:
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Year: 2009 PMID： 19391593 DOI： 10.1021/jo9003508
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354