Literature DB >> 19387769

Hydroxychavicol: a potent xanthine oxidase inhibitor obtained from the leaves of betel, Piper betle.

Kazuya Murata1, Kikuyo Nakao, Noriko Hirata, Kensuke Namba, Takao Nomi, Yoshihisa Kitamura, Kenzo Moriyama, Takahiro Shintani, Munekazu Iinuma, Hideaki Matsuda.   

Abstract

The screening of Piperaceous plants for xanthine oxidase inhibitory activity revealed that the extract of the leaves of Piper betle possesses potent activity. Activity-guided purification led us to obtain hydroxychavicol as an active principle. Hydroxychavicol is a more potent xanthine oxidase inhibitor than allopurinol, which is clinically used for the treatment of hyperuricemia.

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Year:  2009        PMID： 19387769     DOI： 10.1007/s11418-009-0331-y

Source DB:  PubMed          Journal:  J Nat Med        ISSN： 1340-3443            Impact factor:   2.343


  12 in total

1.  Antioxidant activity of piper betel leaf extract and its constituents.

Authors:  Jitesh S Rathee; Birija S Patro; Soumyaditya Mula; Sunita Gamre; Subrata Chattopadhyay
Journal:  J Agric Food Chem       Date:  2006-11-29       Impact factor: 5.279

2.  Structure-antioxidant activity relationships of flavonoids and phenolic acids.

Authors:  C A Rice-Evans; N J Miller; G Paganga
Journal:  Free Radic Biol Med       Date:  1996       Impact factor: 7.376

3.  Structural aspects of antioxidant activity of flavonoids.

Authors:  S A van Acker; D J van den Berg; M N Tromp; D H Griffioen; W P van Bennekom; W J van der Vijgh; A Bast
Journal:  Free Radic Biol Med       Date:  1996       Impact factor: 7.376

4.  Studies on milk xanthine oxidase. Some spectral and kinetic properties.

Authors:  V Massey; P E Brumby; H Komai
Journal:  J Biol Chem       Date:  1969-04-10       Impact factor: 5.157

5.  The antioxidant and radical scavenging activities of black pepper (Piper nigrum) seeds.

Authors:  Ilhami Gülçin
Journal:  Int J Food Sci Nutr       Date:  2005-11       Impact factor: 3.833

6.  Inhibition of xanthine oxidase by flavonoids.

Authors:  A Nagao; M Seki; H Kobayashi
Journal:  Biosci Biotechnol Biochem       Date:  1999-10       Impact factor: 2.043

7.  Xanthine oxidase inhibitors from the flowers of Chrysanthemum sinense.

Authors:  Mai Thanh Nguyen; Suresh Awale; Yasuhiro Tezuka; Jun-ya Ueda; Quan le Tran; Shigetoshi Kadota
Journal:  Planta Med       Date:  2006-01       Impact factor: 3.352

8.  Antioxidative and antiplatelet effects of aqueous inflorescence Piper betle extract.

Authors:  Daniel Lei; Chiu-Po Chan; Ying-Jan Wang; Tong-Mei Wang; Bor-Ru Lin; Chun-Hsun Huang; Jang-Jaer Lee; Hsin-Ming Chen; Jiiang-Huei Jeng; Mei-Chi Chang
Journal:  J Agric Food Chem       Date:  2003-03-26       Impact factor: 5.279

9.  Inhibitory effects of flavonoids on xanthine oxidase.

Authors:  W S Chang; Y J Lee; F J Lu; H C Chiang
Journal:  Anticancer Res       Date:  1993 Nov-Dec       Impact factor: 2.480

10.  Anti-gout agent allopurinol exerts cytotoxicity to human hormone-refractory prostate cancer cells in combination with tumor necrosis factor-related apoptosis-inducing ligand.

Authors:  Takashi Yasuda; Tatsushi Yoshida; Ahmed E Goda; Mano Horinaka; Kimihiro Yano; Takumi Shiraishi; Miki Wakada; Yoichi Mizutani; Tsuneharu Miki; Toshiyuki Sakai
Journal:  Mol Cancer Res       Date:  2008-12       Impact factor: 5.852
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  7 in total

1.  3,4-Dihydroxy-5-nitrobenzaldehyde (DHNB) is a potent inhibitor of xanthine oxidase: a potential therapeutic agent for treatment of hyperuricemia and gout.

Authors:  Jian-Ming Lü; Qizhi Yao; Changyi Chen
Journal:  Biochem Pharmacol       Date:  2013-08-30       Impact factor: 5.858

2.  A comparative study of AutoDock and PMF scoring performances, and SAR of 2-substituted pyrazolotriazolopyrimidines and 4-substituted pyrazolopyrimidines as potent xanthine oxidase inhibitors.

Authors:  Hamed I Ali; Takayuki Fujita; Eiichi Akaho; Tomohisa Nagamatsu
Journal:  J Comput Aided Mol Des       Date:  2009-12-29       Impact factor: 3.686

3.  Design and synthesis of chalcone derivatives as potential non-purine xanthine oxidase inhibitors.

Authors:  Trung Huu Bui; Nhan Trung Nguyen; Phu Hoang Dang; Hai Xuan Nguyen; Mai Thanh Thi Nguyen
Journal:  Springerplus       Date:  2016-10-13

4.  Rhaponticum acaule (L) DC essential oil: chemical composition, in vitro antioxidant and enzyme inhibition properties.

Authors:  Habib Mosbah; Hassiba Chahdoura; Jannet Kammoun; Malek Besbes Hlila; Hanen Louati; Saoussen Hammami; Guido Flamini; Lotfi Achour; Boulbaba Selmi
Journal:  BMC Complement Altern Med       Date:  2018-03-05       Impact factor: 3.659

Review 5.  Anti-gout Potential of Malaysian Medicinal Plants.

Authors:  Fazleen I Abu Bakar; Mohd F Abu Bakar; Asmah Rahmat; Norazlin Abdullah; Siti F Sabran; Susi Endrini
Journal:  Front Pharmacol       Date:  2018-03-23       Impact factor: 5.810

6.  Biological and Cytoprotective Effect of Piper kadsura Ohwi against Hydrogen-Peroxide-Induced Oxidative Stress in Human SW1353 Cells.

Authors:  Te-Yang Huang; Chih-Chuan Wu; Wen-Ta Su
Journal:  Molecules       Date:  2021-10-18       Impact factor: 4.411

7.  Cleroda-4(18),13-dien-15,16-olide as novel xanthine oxidase inhibitors: An integrated in silico and in vitro study.

Authors:  Ha Thi Nguyen; Thien-Y Vu; Tikam Chand Dakal; Bhanupriya Dhabhai; Xuan Hong Quan Nguyen; Vinay Bharadwaj Tatipamula
Journal:  PLoS One       Date:  2021-06-30       Impact factor: 3.240
  7 in total

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