| Literature DB >> 16450295 |
Mai Thanh Nguyen1, Suresh Awale, Yasuhiro Tezuka, Jun-ya Ueda, Quan le Tran, Shigetoshi Kadota.
Abstract
From the MeOH extract of the flowers of Chrysanthemum sinense, a new flavone glucoside, acacetin 7- O-(3- O-acetyl- beta- D-glucopyranoside), has been isolated together with 27 known compounds including flavonoids, caffeoylquinic acid derivatives, phenolics, and a monoterpenoid glucoside. Their structures were elucidated on the basis of spectroscopic data. Compounds and displayed significant xanthine oxidase inhibitory activity in a concentration-dependent manner, and compounds and showed more potent inhibitory activity, with IC50 values ranging from 0.13 to 2.31 microM, than that of a positive control allopurinol (IC50=2.50 microM). The kinetic study indicated that and displayed competitive-type inhibition like that of allopurinol, while displayed a mixed-type inhibition.Entities:
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Year: 2006 PMID： 16450295 DOI： 10.1055/s-2005-873181
Source DB: PubMed Journal: Planta Med ISSN： 0032-0943 Impact factor: 3.352