Literature DB >> 19383356

Circulating tumour cells as a predictive factor for response to systemic chemotherapy in patients with advanced colorectal cancer.

Silke Lankiewicz1, Silke Zimmermann, Christiane Hollmann, Tina Hillemann, Tim F Greten.   

Abstract

Circulating tumour cells (CTC) can be traced in patients with different types of cancer. The aim of this study was to detect CTC in patients with advanced colorectal cancer and whether CTC are still detectable after systemic chemotherapy. Blood from 34 patients with advanced colorectal cancer was analysed for the presence of CTC before chemotherapy was given and after 3 months. Eleven patients demonstrated a tumour remission after chemotherapy. In 6 cases CTC were detectable before but not after initiation of chemotherapy. Ten patients demonstrated a progression. In 5 cases CTC were detected before and after chemotherapy. Our data suggest that the detection of CTC will help to identify patients responding to chemotherapy or with a risk of a therapy failure.

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Year:  2008        PMID： 19383356      PMCID： PMC5527776          DOI： 10.1016/j.molonc.2008.09.001

Source DB:  PubMed          Journal:  Mol Oncol        ISSN： 1574-7891            Impact factor:   6.603


  33 in total

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Journal:  Clin Colorectal Cancer       Date:  2006-07       Impact factor: 4.481

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Review 5.  Novel approaches to treatment of advanced colorectal cancer with anti-EGFR monoclonal antibodies.

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8.  Circulating tumour cells as a predictive factor for response to systemic chemotherapy in patients with advanced colorectal cancer.

Authors:  Silke Lankiewicz; Silke Zimmermann; Christiane Hollmann; Tina Hillemann; Tim F Greten
Journal:  Mol Oncol       Date:  2008-09-16       Impact factor: 6.603

Review 9.  Molecular detection of circulating cancer cells. Role in diagnosis, prognosis and follow-up of colon cancer patients.

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  10 in total

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6.  Circulating tumour cells as a predictive factor for response to systemic chemotherapy in patients with advanced colorectal cancer.

Authors:  Silke Lankiewicz; Silke Zimmermann; Christiane Hollmann; Tina Hillemann; Tim F Greten
Journal:  Mol Oncol       Date:  2008-09-16       Impact factor: 6.603

7.  Correlation between Cancer Stem Cells and Circulating Tumor Cells and Their Value.

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  10 in total

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