OBJECTIVE: To prospectively assess the outcome of children diagnosed with Guillain-Barré syndrome (GBS), followed up for a median duration of 25 months. METHODS: Tertiary center, prospective follow up of children with GBS enrolled between, Dec 2003 to Sep 2006. Functional recovery was determined at 12 months and later using Hughes scale (0-6). Clinical, electrophysiological variables were compared between the good outcome (grade 0/1) and bad outcome groups (died or functional grade >1). RESULTS: Among 52 children with a median age of five yr there was male preponderance (75.4%). Mortality during acute phase was 11.5% (6/52). Among the survivors long term data was obtainable in 40 of the 46 children. At one year follow up 87.5% children had fully recovered or had minimal symptoms, beyond one year this rose to 95%. Only 2 among 40 had significant symptoms at last follow up (1 grade-2 and 1 grade-3). Factors significantly associated with poor outcome were: need for artificial ventilation, inexitable nerves on nerve conduction testing and delayed independent walking. CONCLUSION: Children needing ventilation have the worst short-term prognosis. However, irrespective of severity during acute phase, good long-term recovery can be expected in most children.
OBJECTIVE: To prospectively assess the outcome of children diagnosed with Guillain-Barré syndrome (GBS), followed up for a median duration of 25 months. METHODS: Tertiary center, prospective follow up of children with GBS enrolled between, Dec 2003 to Sep 2006. Functional recovery was determined at 12 months and later using Hughes scale (0-6). Clinical, electrophysiological variables were compared between the good outcome (grade 0/1) and bad outcome groups (died or functional grade >1). RESULTS: Among 52 children with a median age of five yr there was male preponderance (75.4%). Mortality during acute phase was 11.5% (6/52). Among the survivors long term data was obtainable in 40 of the 46 children. At one year follow up 87.5% children had fully recovered or had minimal symptoms, beyond one year this rose to 95%. Only 2 among 40 had significant symptoms at last follow up (1 grade-2 and 1 grade-3). Factors significantly associated with poor outcome were: need for artificial ventilation, inexitable nerves on nerve conduction testing and delayed independent walking. CONCLUSION:Children needing ventilation have the worst short-term prognosis. However, irrespective of severity during acute phase, good long-term recovery can be expected in most children.
Authors: R A C Hughes; E F M Wijdicks; R Barohn; E Benson; D R Cornblath; A F Hahn; J M Meythaler; R G Miller; J T Sladky; J C Stevens Journal: Neurology Date: 2003-09-23 Impact factor: 9.910
Authors: Farrah J Mateen; David R Cornblath; Hamid Jafari; Russell T Shinohara; Devendra Khandit; Bina Ahuja; Sunil Bahl; Roland W Sutter Journal: Vaccine Date: 2011-10-11 Impact factor: 3.641
Authors: Mohammad Barzegar; Vahideh Toopchizadeh; Mohammad H K Maher; Paria Sadeghi; Fatemeh Jahanjoo; Alireza Pishgahi Journal: Pediatr Res Date: 2017-05-17 Impact factor: 3.756