Bahadır Konuşkan1, Çetin Okuyaz2, Bahar Taşdelen3, Semra Hiz Kurul4, Banu Anlar1. 1. Department of Pediatric Neurology, Hacettepe University Faculty of Medicine, Ankara, Turkey. 2. Department of Pediatric Neurology, Mersin University Faculty of Medicine, Mersin, Turkey. 3. Department of Biostatistics, Mersin University Faculty of Medicine, Mersin, Turkey. 4. Department of Pediatric Neurology, Dokuz Eylül University Faculty of Medicine, İzmir, Turkey.
Abstract
INTRODUCTION: We assessed the clinical, epidemiologic, electrophysiological and prognostic characteristics of childhood Guillain-Barré Syndrome admitted to 13 pediatric neurology centers in Turkey. METHOD: Using a standard data recording form age, sex, duration of symptoms, distribution of weakness at onset, cranial nerve involvement, cerebrospinal fluid findings, electrophysiological findings, duration of hospitalization, requirement of ventilation, treatment and clinical evaluation scale at onset, discharge and 1, 3, 6, and 12 months after discharge were recorded. RESULTS: Among the 236 children with a median age of 6.8 years there was a male to female ratio of 1.3. Based on the electrophysiological features; 84 patients were classified as acute inflammatory demyelinating polyrediculoneuropathy (AIDP), 61 as acute motor axonal neuropathy (AMAN), 21 as acute motor-sensory axonal neuropathy (AMSAN). The incidence of cranial nerve involvement was 16%, and was related to lower clinical scores at discharge and 6 months after discharge. Clinical scale scores between axonal and demyelinating subgroups did not show statistically significant difference except for admission (p<0.05). CONCLUSION: Electrophysiological subtypes are not important in prognosis in our series. However, duration of weakness, duration of hospitalization and ventilation requirement can affect prognosis negatively.
INTRODUCTION: We assessed the clinical, epidemiologic, electrophysiological and prognostic characteristics of childhood Guillain-Barré Syndrome admitted to 13 pediatric neurology centers in Turkey. METHOD: Using a standard data recording form age, sex, duration of symptoms, distribution of weakness at onset, cranial nerve involvement, cerebrospinal fluid findings, electrophysiological findings, duration of hospitalization, requirement of ventilation, treatment and clinical evaluation scale at onset, discharge and 1, 3, 6, and 12 months after discharge were recorded. RESULTS: Among the 236 children with a median age of 6.8 years there was a male to female ratio of 1.3. Based on the electrophysiological features; 84 patients were classified as acute inflammatory demyelinating polyrediculoneuropathy (AIDP), 61 as acute motor axonal neuropathy (AMAN), 21 as acute motor-sensory axonal neuropathy (AMSAN). The incidence of cranial nerve involvement was 16%, and was related to lower clinical scores at discharge and 6 months after discharge. Clinical scale scores between axonal and demyelinating subgroups did not show statistically significant difference except for admission (p<0.05). CONCLUSION: Electrophysiological subtypes are not important in prognosis in our series. However, duration of weakness, duration of hospitalization and ventilation requirement can affect prognosis negatively.
Authors: Joyce Roodbol; Marie-Claire Y de Wit; Femke K Aarsen; Coriene E Catsman-Berrevoets; Bart C Jacobs Journal: J Peripher Nerv Syst Date: 2014-06 Impact factor: 3.494