Literature DB >> 19376174

Spatial regulation of specific gene expression through photoactivation of RNAi.

Tamaki Endoh1, Masahiko Sisido, Takashi Ohtsuki.   

Abstract

In this study we describe the spatial regulation of RNA interference (RNAi) using an RNA-carrier protein labeled with a fluorescent dye and a light source to trigger the RNAi. We demonstrate photo-dependent gene silencing using several dyes with different excitation wavelengths. Additionally, we use light from a halogen lamp and a photomask to produce photopatterned RNAi, and laser light to trigger single-cell RNAi on cell culture plates.

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Year:  2009        PMID: 19376174     DOI: 10.1016/j.jconrel.2009.04.015

Source DB:  PubMed          Journal:  J Control Release        ISSN: 0168-3659            Impact factor:   9.776


  18 in total

1.  TAT-mediated photochemical internalization results in cell killing by causing the release of calcium into the cytosol of cells.

Authors:  Nandhini Muthukrishnan; Gregory A Johnson; Jongdoo Lim; Eric E Simanek; Jean-Philippe Pellois
Journal:  Biochim Biophys Acta       Date:  2012-07-03

Review 2.  Optochemical Control of Biological Processes in Cells and Animals.

Authors:  Nicholas Ankenbruck; Taylor Courtney; Yuta Naro; Alexander Deiters
Journal:  Angew Chem Int Ed Engl       Date:  2018-02-01       Impact factor: 15.336

Review 3.  Endosomal Escape and Cytosolic Penetration of Macromolecules Mediated by Synthetic Delivery Agents.

Authors:  Dakota J Brock; Helena M Kondow-McConaghy; Elizabeth C Hager; Jean-Philippe Pellois
Journal:  Bioconjug Chem       Date:  2018-12-06       Impact factor: 4.774

4.  Synergy between cell-penetrating peptides and singlet oxygen generators leads to efficient photolysis of membranes.

Authors:  Nandhini Muthukrishnan; Gregory A Johnson; Alfredo Erazo-Oliveras; Jean-Philippe Pellois
Journal:  Photochem Photobiol       Date:  2013-01-29       Impact factor: 3.421

Review 5.  Membrane Oxidation in Cell Delivery and Cell Killing Applications.

Authors:  Ting-Yi Wang; M Daben J Libardo; Alfredo M Angeles-Boza; Jean-Philippe Pellois
Journal:  ACS Chem Biol       Date:  2017-04-10       Impact factor: 5.100

6.  The photolytic activity of poly-arginine cell penetrating peptides conjugated to carboxy-tetramethylrhodamine is modulated by arginine residue content and fluorophore conjugation site.

Authors:  Nandhini Muthukrishnan; Stephen Donovan; Jean-Philippe Pellois
Journal:  Photochem Photobiol       Date:  2014-06-03       Impact factor: 3.421

7.  Photoactivation of sulfonated polyplexes enables localized gene silencing by DsiRNA in breast cancer cells.

Authors:  Anu Puri; Mathias Viard; Paul Zakrevsky; Serena Zampino; Arabella Chen; Camryn Isemann; Sohaib Alvi; Jeff Clogston; Upendra Chitgupi; Jonathan F Lovell; Bruce A Shapiro
Journal:  Nanomedicine       Date:  2020-03-06       Impact factor: 5.307

Review 8.  Light activation as a method of regulating and studying gene expression.

Authors:  Alexander Deiters
Journal:  Curr Opin Chem Biol       Date:  2009-10-24       Impact factor: 8.822

9.  The synthesis of tetra-modified RNA for the multidimensional control of gene expression via light-activated RNA interference.

Authors:  Ashish Kala; Piyush K Jain; Dipu Karunakaran; Samit Shah; Simon H Friedman
Journal:  Nat Protoc       Date:  2013-12-05       Impact factor: 13.491

10.  Photodamage of lipid bilayers by irradiation of a fluorescently labeled cell-penetrating peptide.

Authors:  Igor Meerovich; Nandhini Muthukrishnan; Gregory A Johnson; Alfredo Erazo-Oliveras; Jean-Philippe Pellois
Journal:  Biochim Biophys Acta       Date:  2013-10-14
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