Literature DB >> 19373810

Efficient catalytic promiscuity for chemically distinct reactions.

Ann C Babtie1, Subhajit Bandyopadhyay, Luis F Olguin, Florian Hollfelder.   

Abstract

High catalytic proficiencies observed for the native and promiscuous reaction of the Pseudomonas aeruginosa arylsulfatase (PAS; the picture shows transition states of the two substrates with corresponding binding constants K(tx)) suggest that the trade-off between high activity and tight specificity can be substantially relaxed.

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Year:  2009        PMID： 19373810     DOI： 10.1002/anie.200805843

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  18 in total

1.  An efficient, multiply promiscuous hydrolase in the alkaline phosphatase superfamily.

Authors:  Bert van Loo; Stefanie Jonas; Ann C Babtie; Alhosna Benjdia; Olivier Berteau; Marko Hyvönen; Florian Hollfelder
Journal:  Proc Natl Acad Sci U S A       Date:  2010-01-27       Impact factor: 11.205

2.  Evolutionary repurposing of a sulfatase: A new Michaelis complex leads to efficient transition state charge offset.

Authors:  Charlotte M Miton; Stefanie Jonas; Gerhard Fischer; Fernanda Duarte; Mark F Mohamed; Bert van Loo; Bálint Kintses; Shina C L Kamerlin; Nobuhiko Tokuriki; Marko Hyvönen; Florian Hollfelder
Journal:  Proc Natl Acad Sci U S A       Date:  2018-07-16       Impact factor: 11.205

3.  Differential catalytic promiscuity of the alkaline phosphatase superfamily bimetallo core reveals mechanistic features underlying enzyme evolution.

Authors:  Fanny Sunden; Ishraq AlSadhan; Artem Lyubimov; Tzanko Doukov; Jeffrey Swan; Daniel Herschlag
Journal:  J Biol Chem       Date:  2017-10-25       Impact factor: 5.157

4.  An evolutionary biochemist's perspective on promiscuity.

Authors:  Shelley D Copley
Journal:  Trends Biochem Sci       Date:  2015-01-05       Impact factor: 13.807

Review 5.  Computer aided enzyme design and catalytic concepts.

Authors:  Maria P Frushicheva; Matthew J L Mills; Patrick Schopf; Manoj K Singh; Ram B Prasad; Arieh Warshel
Journal:  Curr Opin Chem Biol       Date:  2014-05-08       Impact factor: 8.822

6.  QM/MM free energy simulations: recent progress and challenges.

Authors:  Xiya Lu; Dong Fang; Shingo Ito; Yuko Okamoto; Victor Ovchinnikov; Qiang Cui
Journal:  Mol Simul       Date:  2016-07-05       Impact factor: 2.178

Review 7.  Why nature really chose phosphate.

Authors:  Shina C L Kamerlin; Pankaz K Sharma; Ram B Prasad; Arieh Warshel
Journal:  Q Rev Biophys       Date:  2013-01-15       Impact factor: 5.318

8.  Site-directed mutagenesis maps interactions that enhance cognate and limit promiscuous catalysis by an alkaline phosphatase superfamily phosphodiesterase.

Authors:  Helen Wiersma-Koch; Fanny Sunden; Daniel Herschlag
Journal:  Biochemistry       Date:  2013-12-11       Impact factor: 3.162

9.  Probing the mutational interplay between primary and promiscuous protein functions: a computational-experimental approach.

Authors:  Hector Garcia-Seisdedos; Beatriz Ibarra-Molero; Jose M Sanchez-Ruiz
Journal:  PLoS Comput Biol       Date:  2012-06-14       Impact factor: 4.475

Review 10.  Computational protein engineering: bridging the gap between rational design and laboratory evolution.

Authors:  Alexandre Barrozo; Rok Borstnar; Gaël Marloie; Shina Caroline Lynn Kamerlin
Journal:  Int J Mol Sci       Date:  2012-09-28       Impact factor: 5.923
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