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Literature DB >> 19362634

Structural enzymology of polyketide synthases.

Shiou-Chuan Sheryl Tsai¹, Brian Douglas Ames.

Abstract

This chapter describes structural and associated enzymological studies of polyketide synthases, including isolated single domains and multidomain fragments. The sequence-structure-function relationship of polyketide biosynthesis, compared with homologous fatty acid synthesis, is discussed in detail. Structural enzymology sheds light on sequence and structural motifs that are important for the precise timing, substrate recognition, enzyme catalysis, and protein-protein interactions leading to the extraordinary structural diversity of naturally occurring polyketides.

Entities: Chemical Disease Gene Species

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Year: 2009 PMID： 19362634 PMCID： PMC2873140 DOI： 10.1016/S0076-6879(09)04602-3

Source DB: PubMed Journal: Methods Enzymol ISSN： 0076-6879 Impact factor: 1.600

126 in total

1. High-throughput mutagenesis to evaluate models of stereochemical control in ketoreductase domains from the erythromycin polyketide synthase.

Authors: Helen M O'Hare; Abel Baerga-Ortiz; Bojana Popovic; Jonathan B Spencer; Peter F Leadlay
Journal: Chem Biol Date: 2006-03

2. Quantitative analysis of loading and extender acyltransferases of modular polyketide synthases.

Authors: Grace F Liou; Janice Lau; David E Cane; Chaitan Khosla
Journal: Biochemistry Date: 2003-01-14 Impact factor: 3.162

3. Active-site residue, domain and module swaps in modular polyketide synthases.

Authors: Francesca Del Vecchio; Hrvoje Petkovic; Steven G Kendrew; Lindsey Low; Barrie Wilkinson; Rachel Lill; Jesús Cortés; Brian A M Rudd; Jim Staunton; Peter F Leadlay
Journal: J Ind Microbiol Biotechnol Date: 2003-06-14 Impact factor: 3.346

4. Chain initiation on type I modular polyketide synthases revealed by limited proteolysis and ion-trap mass spectrometry.

Authors: Hui Hong; Antony N Appleyard; Alexandros P Siskos; Jose Garcia-Bernardo; James Staunton; Peter F Leadlay
Journal: FEBS J Date: 2005-05 Impact factor: 5.542

5. Heterologous expression, purification, reconstitution and kinetic analysis of an extended type II polyketide synthase.

Authors: R J Zawada; C Khosla
Journal: Chem Biol Date: 1999-09

6. Engineered biosynthesis of bacterial aromatic polyketides in Escherichia coli.

Authors: Wenjun Zhang; Yanran Li; Yi Tang
Journal: Proc Natl Acad Sci U S A Date: 2008-12-15 Impact factor: 11.205

7. Cloning and heterologous expression of a gene cluster for the biosynthesis of tetracenomycin C, the anthracycline antitumor antibiotic of Streptomyces glaucescens.

Authors: H Motamedi; C R Hutchinson
Journal: Proc Natl Acad Sci U S A Date: 1987-07 Impact factor: 11.205

8. Cofactor-induced conformational rearrangements establish a catalytically competent active site and a proton relay conduit in FabG.

Authors: Allen C Price; Yong-Mei Zhang; Charles O Rock; Stephen W White
Journal: Structure Date: 2004-03 Impact factor: 5.006

9. Key residues responsible for acyl carrier protein and beta-ketoacyl-acyl carrier protein reductase (FabG) interaction.

Authors: Yong-Mei Zhang; Bainan Wu; Jie Zheng; Charles O Rock
Journal: J Biol Chem Date: 2003-10-03 Impact factor: 5.157

10. The Hotdog fold: wrapping up a superfamily of thioesterases and dehydratases.

Authors: Shane C Dillon; Alex Bateman
Journal: BMC Bioinformatics Date: 2004-08-12 Impact factor: 3.169

18 in total

1. An Oxetane-Based Polyketide Surrogate To Probe Substrate Binding in a Polyketide Synthase.

Authors: Bryan D Ellis; Jacob C Milligan; Alexander R White; Vy Duong; Pilar X Altman; Lina Y Mohammed; Matthew P Crump; John Crosby; Ray Luo; Christopher D Vanderwal; Shiou-Chuan Tsai
Journal: J Am Chem Soc Date: 2018-04-10 Impact factor: 15.419

Review 2. Cyclization of aromatic polyketides from bacteria and fungi.

Authors: Hui Zhou; Yanran Li; Yi Tang
Journal: Nat Prod Rep Date: 2010-03-31 Impact factor: 13.423

3. Binding and "pKa" modulation of a polycyclic substrate analogue in a type II polyketide acyl carrier protein.

Authors: Robert W Haushalter; Fabian V Filipp; Kwang-Seuk Ko; Ricky Yu; Stanley J Opella; Michael D Burkart
Journal: ACS Chem Biol Date: 2011-02-22 Impact factor: 5.100

4. Limitations of the 'ambush hypothesis' at the single-gene scale: what codon biases are to blame?

Authors: Robert L Bertrand; Mona Abdel-Hameed; John L Sorensen
Journal: Mol Genet Genomics Date: 2014-10-12 Impact factor: 3.291

5. Enzyme That Makes You Cry-Crystal Structure of Lachrymatory Factor Synthase from Allium cepa.

Authors: Josie A Silvaroli; Matthew J Pleshinger; Surajit Banerjee; Philip D Kiser; Marcin Golczak
Journal: ACS Chem Biol Date: 2017-07-26 Impact factor: 5.100

6. Unique features of the ketosynthase domain in a nonribosomal peptide synthetase-polyketide synthase hybrid enzyme, tenuazonic acid synthetase 1.

Authors: Choong-Soo Yun; Kazuki Nishimoto; Takayuki Motoyama; Takeshi Shimizu; Tomoya Hino; Naoshi Dohmae; Shingo Nagano; Hiroyuki Osada
Journal: J Biol Chem Date: 2020-06-21 Impact factor: 5.157

7. One-Pot Enzymatic Total Synthesis of Presteffimycinone, an Early Intermediate of the Anthracycline Antibiotic Steffimycin Biosynthesis.

Authors: Guojun Wang; Jing Chen; Haining Zhu; Jürgen Rohr
Journal: Org Lett Date: 2017-01-19 Impact factor: 6.005