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Literature DB >> 19332681

Concentrations of voriconazole in healthy and inflamed lung in rats.

Christian Joukhadar¹, Christiane Thallinger, Wolfgang Pöppl, Florian Kovar, Karl H Konz, Samir M Joukhadar, Friederike Traunmüller.

Abstract

By utilizing the microdialysis technique, we investigated the pharmacokinetic profile of voriconazole in the interstitium of the lungs and skeletal muscle tissue of rats after a single intravenous dose under healthy and inflammatory conditions. As expected, voriconazole penetrated excellently into the interstitium of tissues, and its levels were descriptively almost identical to free concentration-versus-time profiles in plasma.

Entities: Chemical Species

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Year: 2009 PMID： 19332681 PMCID： PMC2687183 DOI： 10.1128/AAC.00885-08

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

13 in total

Review 1. Lung microdialysis--a powerful tool for the determination of exogenous and endogenous compounds in the lower respiratory tract (mini-review).

Authors: Markus Zeitlinger; Markus Müller; Christian Joukhadar
Journal: AAPS J Date: 2005-10-22 Impact factor: 4.009

2. Isocratic high-performance liquid chromatographic method with ultraviolet detection for simultaneous determination of levels of voriconazole and itraconazole and its hydroxy metabolite in human serum.

Authors: GholamAli Khoschsorur; Franz Fruehwirth; Sieglinde Zelzer
Journal: Antimicrob Agents Chemother Date: 2005-08 Impact factor: 5.191

3. Microdialysis study of imipenem distribution in skeletal muscle and lung extracellular fluids of Acinetobacter baumannii-infected rats.

Authors: Claire Dahyot; Sandrine Marchand; Greisiele Lorena Pessini; Claudine Pariat; Bertrand Debaene; William Couet; Olivier Mimoz
Journal: Antimicrob Agents Chemother Date: 2006-06 Impact factor: 5.191

Review 4. Pharmacokinetic/pharmacodynamic profile of voriconazole.

Authors: Ursula Theuretzbacher; Franziska Ihle; Hartmut Derendorf
Journal: Clin Pharmacokinet Date: 2006 Impact factor: 6.447

5. Impaired target site penetration of beta-lactams may account for therapeutic failure in patients with septic shock.

Authors: C Joukhadar; M Frossard; B X Mayer; M Brunner; N Klein; P Siostrzonek; H G Eichler; M Müller
Journal: Crit Care Med Date: 2001-02 Impact factor: 7.598

6. Tissue distribution of imipenem in critically ill patients.

Authors: Irmgard Tegeder; Achim Schmidtko; Lutz Bräutigam; Andreas Kirschbaum; Gerd Geisslinger; Jörn Lötsch
Journal: Clin Pharmacol Ther Date: 2002-05 Impact factor: 6.875

7. Adverse reactions to voriconazole.

Authors: Aileen E Boyd; Simon Modi; Susan J Howard; Caroline B Moore; Brian G Keevil; David W Denning
Journal: Clin Infect Dis Date: 2004-09-23 Impact factor: 9.079

8. In vivo pharmacokinetics and pharmacodynamics of a new triazole, voriconazole, in a murine candidiasis model.

Authors: D Andes; K Marchillo; T Stamstad; R Conklin
Journal: Antimicrob Agents Chemother Date: 2003-10 Impact factor: 5.191

9. The disposition of voriconazole in mouse, rat, rabbit, guinea pig, dog, and human.

Authors: S J Roffey; S Cole; P Comby; D Gibson; S G Jezequel; A N R Nedderman; D A Smith; D K Walker; N Wood
Journal: Drug Metab Dispos Date: 2003-06 Impact factor: 3.922

10. Voriconazole plasma monitoring.

Authors: A C Pasqualotto; M Shah; R Wynn; D W Denning
Journal: Arch Dis Child Date: 2008-02-05 Impact factor: 3.791

5 in total

1. Human tissue distribution of voriconazole.

Authors: Stefan Weiler; David Fiegl; Róisín MacFarland; Eva Stienecke; Rosa Bellmann-Weiler; Stefan Dunzendorfer; Michael Joannidis; Romuald Bellmann
Journal: Antimicrob Agents Chemother Date: 2010-11-15 Impact factor: 5.191

Review 2. Utility of Microdialysis in Infectious Disease Drug Development and Dose Optimization.

Authors: Amelia N Deitchman; M Tobias Heinrichs; Vipada Khaowroongrueng; Satyawan B Jadhav; Hartmut Derendorf
Journal: AAPS J Date: 2016-12-09 Impact factor: 4.009

3. Pilot investigation on long-term subcutaneous microdialysis: proof of principle in humans.

Authors: Franziska Simmel; Claudia Kirbs; Zeynep Erdogan; Edith Lackner; Markus Zeitlinger; Charlotte Kloft
Journal: AAPS J Date: 2012-10-13 Impact factor: 4.009

4. Susceptibility breakpoints for amphotericin B and Aspergillus species in an in vitro pharmacokinetic-pharmacodynamic model simulating free-drug concentrations in human serum.

Authors: A Elefanti; J W Mouton; P E Verweij; L Zerva; J Meletiadis
Journal: Antimicrob Agents Chemother Date: 2014-02-10 Impact factor: 5.191

Review 5. Tissue penetration of antifungal agents.

Authors: Timothy Felton; Peter F Troke; William W Hope
Journal: Clin Microbiol Rev Date: 2014-01 Impact factor: 26.132

5 in total