| Literature DB >> 15486850 |
Aileen E Boyd1, Simon Modi, Susan J Howard, Caroline B Moore, Brian G Keevil, David W Denning.
Abstract
Voriconazole is a new antifungal agent effective in the treatment of invasive aspergillosis. Interpatient variation in plasma concentrations is considerable--more than 100-fold. We describe 3 patients with diverse manifestations of toxicity (e.g., hallucinations, hypoglycemia, electrolyte disturbance, and pneumonitis) possibly attributable to high voriconazole concentrations. Measurement of plasma concentrations could be helpful in optimizing voriconazole dosages.Entities:
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Year: 2004 PMID: 15486850 DOI: 10.1086/424662
Source DB: PubMed Journal: Clin Infect Dis ISSN: 1058-4838 Impact factor: 9.079