Literature DB >> 19324536

Glutamate receptor gene (GRIN2B) associated with reduced anterior cingulate glutamatergic concentration in pediatric obsessive-compulsive disorder.

Paul Daniel Arnold1, Frank P Macmaster, Margaret A Richter, Gregory L Hanna, Tricia Sicard, Eliza Burroughs, Yousha Mirza, Phillip C Easter, Michelle Rose, James L Kennedy, David R Rosenberg.   

Abstract

In this preliminary study, 16 psychotropic-naïve pediatric patients with obsessive-compulsive disorder (OCD) were studied using magnetic resonance spectroscopy (MRS) and genotyped for six candidate polymorphisms in two glutamate system genes. A significant association was identified between the rs1019385 polymorphism of the glutamate receptor, ionotropic, N-methyl-d-aspartate 2B (GRIN2B) and decreased anterior cingulate cortex (ACC) glutamatergic concentration (Glx) but not with occipital Glx. These results suggest that GRIN2B may be associated with Glx in the ACC, a region consistently implicated in OCD.

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Year:  2009        PMID： 19324536      PMCID： PMC2670773          DOI： 10.1016/j.pscychresns.2009.02.005

Source DB:  PubMed          Journal:  Psychiatry Res        ISSN： 0165-1781            Impact factor:   3.222


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