PURPOSE: To evaluate the feasibility of spatially resolving the shear modulus of lung parenchyma using conventional (1)H magnetic resonance elastography (MRE) imaging techniques in a small animal model. MATERIALS AND METHODS: A 10-cm diameter transmit-receive radiofrequency coil was modified to include a specimen stage, an MRE pneumatic drum driver, and needle system. MRE was performed on 10 female Sprague-Dawley rats using a (1)H spin-echo based MRE imaging sequence with a field of view of 7 cm and slice thickness of 5 mm. Air-filled lungs were imaged at transpulmonary inflation pressures of 5, 10, and 15 cm H(2)O while fluid-filled lungs were imaged after infusion of 4 mL of normal saline. RESULTS: The average shear modulus of air-filled lungs was 0.840 +/- 0.0524 kPa, 1.07 +/- 0.114 kPa and 1.30 +/- 0.118 kPa at 5, 10, and 15 cm H(2)O, respectively. Analysis of variance indicated that these population means were statistically significantly different from one another (F-value = 26.279, P = 0.00004). The shear modulus of the fluid-filled lungs was 1.65 +/- 0.360 kPa. CONCLUSION: It is feasible to perform lung MRE in small animals using conventional MR imaging technologies.
PURPOSE: To evaluate the feasibility of spatially resolving the shear modulus of lung parenchyma using conventional (1)H magnetic resonance elastography (MRE) imaging techniques in a small animal model. MATERIALS AND METHODS: A 10-cm diameter transmit-receive radiofrequency coil was modified to include a specimen stage, an MRE pneumatic drum driver, and needle system. MRE was performed on 10 female Sprague-Dawley rats using a (1)H spin-echo based MRE imaging sequence with a field of view of 7 cm and slice thickness of 5 mm. Air-filled lungs were imaged at transpulmonary inflation pressures of 5, 10, and 15 cm H(2)O while fluid-filled lungs were imaged after infusion of 4 mL of normal saline. RESULTS: The average shear modulus of air-filled lungs was 0.840 +/- 0.0524 kPa, 1.07 +/- 0.114 kPa and 1.30 +/- 0.118 kPa at 5, 10, and 15 cm H(2)O, respectively. Analysis of variance indicated that these population means were statistically significantly different from one another (F-value = 26.279, P = 0.00004). The shear modulus of the fluid-filled lungs was 1.65 +/- 0.360 kPa. CONCLUSION: It is feasible to perform lung MRE in small animals using conventional MR imaging technologies.
Authors: Harald E Möller; X Josette Chen; Brian Saam; Klaus D Hagspiel; G Allan Johnson; Talissa A Altes; Eduard E de Lange; Hans-Ulrich Kauczor Journal: Magn Reson Med Date: 2002-06 Impact factor: 4.668
Authors: Alexia L McKnight; Jennifer L Kugel; Phillip J Rossman; Armando Manduca; Lynn C Hartmann; Richard L Ehman Journal: AJR Am J Roentgenol Date: 2002-06 Impact factor: 3.959
Authors: Jeffrey R Basford; Thomas R Jenkyn; Kai-Nan An; Richard L Ehman; Guido Heers; Kenton R Kaufman Journal: Arch Phys Med Rehabil Date: 2002-11 Impact factor: 3.966
Authors: Nihar S Shah; Scott A Kruse; Donna J Lager; Gerard Farell-Baril; John C Lieske; Bernard F King; Richard L Ehman Journal: Magn Reson Med Date: 2004-07 Impact factor: 4.668
Authors: Armen Sarvazyan; Timothy J Hall; Matthew W Urban; Mostafa Fatemi; Salavat R Aglyamov; Brian S Garra Journal: Curr Med Imaging Rev Date: 2011-11
Authors: Yogesh K Mariappan; Kevin J Glaser; Rolf D Hubmayr; Armando Manduca; Richard L Ehman; Kiaran P McGee Journal: J Magn Reson Imaging Date: 2011-06 Impact factor: 4.813