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Literature DB >> 15371335

Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions.

Felix H Brembeck¹, Thomas Schwarz-Romond, Jeroen Bakkers, Sabine Wilhelm, Matthias Hammerschmidt, Walter Birchmeier.

Abstract

beta-Catenin controls both cadherin-mediated cell adhesion and activation of Wnt target genes. We demonstrate here that the beta-catenin-binding protein BCL9-2, a homolog of the human proto-oncogene product BCL9, induces epithelial-mesenchymal transitions of nontransformed cells and increases beta-catenin-dependent transcription. RNA interference of BCL9-2 in carcinoma cells induces an epithelial phenotype and translocates beta-catenin from the nucleus to the cell membrane. The switch between beta-catenin's adhesive and transcriptional functions is modulated by phosphorylation of Tyr 142 of beta-catenin, which favors BCL9-2 binding and precludes interaction with alpha-catenin. During zebrafish embryogenesis, BCL9-2 acts in the Wnt8-signaling pathway and regulates mesoderm patterning.

Entities: Chemical Disease Gene Species

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Year: 2004 PMID： 15371335 PMCID： PMC517514 DOI： 10.1101/gad.317604

Source DB: PubMed Journal: Genes Dev ISSN： 0890-9369 Impact factor: 11.361

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