Literature DB >> 16872146

Antibiotic bisanthraquinones produced by a streptomycete isolated from a cyanobacterium associated with Ecteinascidia turbinata.

Aaron M Socha1, Dioscaris Garcia, Roberta Sheffer, David C Rowley.   

Abstract

Chemical studies of a streptomycete isolated from a cyanobacterium associated with the tropical tunicate Ecteinascidia turbinata led to the bioassay-guided purification of two antibacterial bisanthraquinone metabolites and a cytotoxic artifact. The structures, including relative configurations of these octacyclic compounds, were established by spectroscopic analyses. Their potent antibacterial properties (IC(50) = 0.15-130 microM) versus methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis and cytotoxic effects against HCT-116 cells are presented.

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Year:  2006        PMID： 16872146     DOI： 10.1021/np050449b

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  17 in total

Review 1.  Constructing molecular complexity and diversity: total synthesis of natural products of biological and medicinal importance.

Authors:  K C Nicolaou; Christopher R H Hale; Christian Nilewski; Heraklidia A Ioannidou
Journal:  Chem Soc Rev       Date:  2012-06-28       Impact factor: 54.564

2.  Total synthesis: A cascade of new antibiotics.

Authors:  David C Rowley
Journal:  Nat Chem       Date:  2009-05       Impact factor: 24.427

Review 3.  A brief history of antibiotics and select advances in their synthesis.

Authors:  Kyriacos C Nicolaou; Stephan Rigol
Journal:  J Antibiot (Tokyo)       Date:  2017-07-05       Impact factor: 2.649

4.  Origins of regioselectivity of Diels-Alder reactions for the synthesis of bisanthraquinone antibiotic BE-43472B.

Authors:  Amy E Hayden; Robert S Paton; Jochen Becker; Yee Hwee Lim; K C Nicolaou; K N Houk
Journal:  J Org Chem       Date:  2010-02-05       Impact factor: 4.354

Review 5.  Antibacterials from the sea.

Authors:  Chambers C Hughes; William Fenical
Journal:  Chemistry       Date:  2010-11-08       Impact factor: 5.236

6.  Eucapsitrione, an anti-Mycobacterium tuberculosis anthraquinone derivative from the cultured freshwater cyanobacterium Eucapsis sp.

Authors:  Megan Sturdy; Aleksej Krunic; Sanghyun Cho; Scott Franzblau; Jimmy Orjala
Journal:  J Nat Prod       Date:  2010-08-27       Impact factor: 4.050

7.  Total synthesis and absolute configuration of the bisanthraquinone antibiotic BE-43472B.

Authors:  K C Nicolaou; Yee Hwee Lim; Jochen Becker
Journal:  Angew Chem Int Ed Engl       Date:  2009       Impact factor: 15.336

8.  Total synthesis and biological evaluation of (+)- and (-)-bisanthraquinone antibiotic BE-43472B and related compounds.

Authors:  K C Nicolaou; Jochen Becker; Yee Hwee Lim; Alexandre Lemire; Thomas Neubauer; Ana Montero
Journal:  J Am Chem Soc       Date:  2009-10-21       Impact factor: 15.419

Review 9.  Novel anti-infective compounds from marine bacteria.

Authors:  Hafizur Rahman; Brian Austin; Wilfrid J Mitchell; Peter C Morris; Derek J Jamieson; David R Adams; Andrew Mearns Spragg; Michael Schweizer
Journal:  Mar Drugs       Date:  2010-03-05       Impact factor: 5.118

Review 10.  Antimicrobial compounds from marine actinomycetes.

Authors:  Cong Wang; Yuanyu Lu; Shugeng Cao
Journal:  Arch Pharm Res       Date:  2020-07-20       Impact factor: 4.946
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