Literature DB >> 19299126

2-Azidoalkoxy-7-hydro-8-oxoadenine derivatives as TLR7 agonists inducing dendritic cell maturation.

Jimmy J Weterings1, Selina Khan, Gerbrand J van der Heden van Noort, Cornelis J M Melief, Herman S Overkleeft, Sjoerd H van der Burg, Ferry Ossendorp, Gijsbert A van der Marel, Dmitri V Filippov.   

Abstract

The synthesis of an array of 2-azidoalkoxy substituted 7-hydro-8-oxoadenines is described. The relation of the structure of these compounds and their ability to induce maturation of dendritic cells is evaluated.

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Year:  2009        PMID： 19299126     DOI： 10.1016/j.bmcl.2009.02.095

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  9 in total

Review 1.  Comprehensive survey of chemical libraries for drug discovery and chemical biology: 2009.

Authors:  Roland E Dolle; Bertrand Le Bourdonnec; Karin Worm; Guillermo A Morales; Craig J Thomas; Wei Zhang
Journal:  J Comb Chem       Date:  2010-10-05

2.  Structure-activity relationships in human toll-like receptor 7-active imidazoquinoline analogues.

Authors:  Nikunj M Shukla; Subbalakshmi S Malladi; Cole A Mutz; Rajalakshmi Balakrishna; Sunil A David
Journal:  J Med Chem       Date:  2010-06-10       Impact factor: 7.446

3.  Toll-like receptor (TLR)-7 and -8 modulatory activities of dimeric imidazoquinolines.

Authors:  Nikunj M Shukla; Cole A Mutz; Subbalakshmi S Malladi; Hemamali J Warshakoon; Rajalakshmi Balakrishna; Sunil A David
Journal:  J Med Chem       Date:  2012-01-27       Impact factor: 7.446

4.  Structural requirements for TLR7-selective signaling by 9-(4-piperidinylalkyl)-8-oxoadenine derivatives.

Authors:  Hélène G Bazin; Yufeng Li; Juhienah K Khalaf; Sandra Mwakwari; Mark T Livesay; Jay T Evans; David A Johnson
Journal:  Bioorg Med Chem Lett       Date:  2015-01-31       Impact factor: 2.823

5.  Facile syntheses of functionalized toll-like receptor 7 agonists.

Authors:  Babatope Akinbobuyi; Matthew R Byrd; Charles A Chang; Mysa Nguyen; Zacharie J Seifert; Anne-Laure Flamar; Gerard Zurawski; Katherine C Upchurch; SangKon Oh; Stephen H Dempsey; Thomas J Enke; John Le; Hunter J Winstead; José R Boquín; Robert R Kane
Journal:  Tetrahedron Lett       Date:  2015-01-08       Impact factor: 2.415

6.  Antibacterial activities of Groebke-Blackburn-Bienaymé-derived imidazo[1,2-a]pyridin-3-amines.

Authors:  Nikunj M Shukla; Deepak B Salunke; Euna Yoo; Cole A Mutz; Rajalakshmi Balakrishna; Sunil A David
Journal:  Bioorg Med Chem       Date:  2012-08-08       Impact factor: 3.641

7.  Structure-activity relationships in human Toll-like receptor 8-active 2,3-diamino-furo[2,3-c]pyridines.

Authors:  Deepak B Salunke; Euna Yoo; Nikunj M Shukla; Rajalakshmi Balakrishna; Subbalakshmi S Malladi; Katelyn J Serafin; Victor W Day; Xinkun Wang; Sunil A David
Journal:  J Med Chem       Date:  2012-09-07       Impact factor: 7.446

Review 8.  Structural evolution of toll-like receptor 7/8 agonists from imidazoquinolines to imidazoles.

Authors:  Deepender Kaushik; Arshpreet Kaur; Nikolai Petrovsky; Deepak B Salunke
Journal:  RSC Med Chem       Date:  2021-05-14

Review 9.  Evolution of Toll-like receptor 7/8 agonist therapeutics and their delivery approaches: From antiviral formulations to vaccine adjuvants.

Authors:  Sachin Bhagchandani; Jeremiah A Johnson; Darrell J Irvine
Journal:  Adv Drug Deliv Rev       Date:  2021-05-29       Impact factor: 15.470
  9 in total

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