Literature DB >> 25601818

Facile syntheses of functionalized toll-like receptor 7 agonists.

Babatope Akinbobuyi1, Matthew R Byrd1, Charles A Chang2, Mysa Nguyen1, Zacharie J Seifert1, Anne-Laure Flamar3, Gerard Zurawski4, Katherine C Upchurch2, SangKon Oh4, Stephen H Dempsey5, Thomas J Enke5, John Le5, Hunter J Winstead5, José R Boquín5, Robert R Kane6.   

Abstract

Protein conjugates of toll-like receptor 7 agonists have been shown to elicit powerful immune responses. In order to facilitate our studies in this area our group has developed efficient syntheses for a number of functionalized derivatives that retain immune stimulatory activity.

Entities:  

Keywords:  Adenine derivatives; Immune activation; Toll-like receptor; Vaccines

Year:  2015        PMID： 25601818      PMCID： PMC4296738          DOI： 10.1016/j.tetlet.2014.11.126

Source DB:  PubMed          Journal:  Tetrahedron Lett        ISSN： 0040-4039            Impact factor:   2.415


  24 in total

1.  Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells.

Authors:  D Jarrossay; G Napolitani; M Colonna; F Sallusto; A Lanzavecchia
Journal:  Eur J Immunol       Date:  2001-11       Impact factor: 5.532

Review 2.  Toll-like receptors in the induction of the innate immune response.

Authors:  A Aderem; R J Ulevitch
Journal:  Nature       Date:  2000-08-17       Impact factor: 49.962

3.  Synthesis of oligonucleotides containing 2'-deoxy-6-thioguanosine at a predetermined site.

Authors:  M S Christopherson; A D Broom
Journal:  Nucleic Acids Res       Date:  1991-10-25       Impact factor: 16.971

4.  Synthesis and biological evaluation of 8-oxoadenine derivatives as toll-like receptor 7 agonists introducing the antedrug concept.

Authors:  Ayumu Kurimoto; Kazuki Hashimoto; Tomoaki Nakamura; Kei Norimura; Haruhisa Ogita; Haruo Takaku; Roger Bonnert; Tom McInally; Hiroki Wada; Yoshiaki Isobe
Journal:  J Med Chem       Date:  2010-04-08       Impact factor: 7.446

5.  Toll-like receptor (TLR)-7 and -8 modulatory activities of dimeric imidazoquinolines.

Authors:  Nikunj M Shukla; Cole A Mutz; Subbalakshmi S Malladi; Hemamali J Warshakoon; Rajalakshmi Balakrishna; Sunil A David
Journal:  J Med Chem       Date:  2012-01-27       Impact factor: 7.446

6.  Synthesis of 2-alkoxy-8-hydroxyadenylpeptides: towards synthetic epitope-based vaccines.

Authors:  Jimmy J Weterings; Selina Khan; Gerbrand J van der Heden; Jan W Drijfhout; Cornelis J M Melief; Herman S Overkleeft; Sjoerd H van der Burg; Ferry Ossendorp; Gijsbert A van der Marel; Dmitri V Filippov
Journal:  Bioorg Med Chem Lett       Date:  2006-04-11       Impact factor: 2.823

7.  Synthesis and evaluation of 8-oxoadenine derivatives as potent Toll-like receptor 7 agonists with high water solubility.

Authors:  Tomoaki Nakamura; Hiroki Wada; Hirotaka Kurebayashi; Tom McInally; Roger Bonnert; Yoshiaki Isobe
Journal:  Bioorg Med Chem Lett       Date:  2012-12-05       Impact factor: 2.823

8.  Synthesis and bronchodilating activity of 2,9-disubstituted adenine derivatives BB-1502 (9-cyclohexyl-2-n-propoxy-9H-adenine) and its analogs.

Authors:  T Naito; S Nakagawa; T Okita; H Yamashita; T Yamasaki; H Kamei; K Tomatsu; H Imanishi; H Kawaguchi
Journal:  Chem Pharm Bull (Tokyo)       Date:  1982-06       Impact factor: 1.645

9.  Synthesis and immunological characterization of toll-like receptor 7 agonistic conjugates.

Authors:  Michael Chan; Tomoko Hayashi; Crystal S Kuy; Christine S Gray; Christina C N Wu; Maripat Corr; Wolfgang Wrasidlo; Howard B Cottam; Dennis A Carson
Journal:  Bioconjug Chem       Date:  2009-06       Impact factor: 4.774

10.  Potent adjuvanticity of a pure TLR7-agonistic imidazoquinoline dendrimer.

Authors:  Nikunj M Shukla; Deepak B Salunke; Rajalakshmi Balakrishna; Cole A Mutz; Subbalakshmi S Malladi; Sunil A David
Journal:  PLoS One       Date:  2012-08-28       Impact factor: 3.240
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