OBJECTIVE: The aim was to compare osseointegration of blood perfused beta-tricalcium phosphate cylinders (beta-TCPB) with similar composites that were additionally loaded with cancellous bone and bone marrow (beta-TCPB/BM/CB) for mandibular reconstruction. METHODS: Twelve German Black-Headed sheep with an average weight of 72.5 +/- 10 kg underwent segmental resection of the right hemi-mandible. The animals that were assigned to group A (n = 6) were reconstructed using beta-TCPB while the sheep that were assigned to group B received beta-TCPB/BM/CB grafts. Tissue quality was histologically assessed and bone-, scaffold-, cartilage- and fibrous-tissue area were estimated using semiautomated histomorphometrical software. RESULTS: Composite grafts that were loaded with bone marrow and cancellous bone (beta-TCPB/BM/CB) exhibited significant (p<0.01) higher amounts of bone formation than beta-TCPB. The patients that were assigned to group B achieved defect union and a high grade of bone maturation. Residual ceramic remnants were rare and disconnected. Bone maturity within group A was inferior and none of the specimens showed defect union. The defect centre was still occupied by a ceramic core. CLINICAL SIGNIFICANCE: Bone and bone marrow augmented beta-tricalcium phosphate composites may qualify as a promising alternative to autograft bone for mandibular reconstruction in human and veterinary medicine.
OBJECTIVE: The aim was to compare osseointegration of blood perfused beta-tricalcium phosphate cylinders (beta-TCPB) with similar composites that were additionally loaded with cancellous bone and bone marrow (beta-TCPB/BM/CB) for mandibular reconstruction. METHODS: Twelve German Black-Headed sheep with an average weight of 72.5 +/- 10 kg underwent segmental resection of the right hemi-mandible. The animals that were assigned to group A (n = 6) were reconstructed using beta-TCPB while the sheep that were assigned to group B received beta-TCPB/BM/CB grafts. Tissue quality was histologically assessed and bone-, scaffold-, cartilage- and fibrous-tissue area were estimated using semiautomated histomorphometrical software. RESULTS: Composite grafts that were loaded with bone marrow and cancellous bone (beta-TCPB/BM/CB) exhibited significant (p<0.01) higher amounts of bone formation than beta-TCPB. The patients that were assigned to group B achieved defect union and a high grade of bone maturation. Residual ceramic remnants were rare and disconnected. Bone maturity within group A was inferior and none of the specimens showed defect union. The defect centre was still occupied by a ceramic core. CLINICAL SIGNIFICANCE: Bone and bone marrow augmented beta-tricalcium phosphate composites may qualify as a promising alternative to autograft bone for mandibular reconstruction in human and veterinary medicine.
Authors: Kevin M Urlaub; Russell E Ettinger; Noah S Nelson; Jessie M Hoxie; Alicia E Snider; Joseph E Perosky; Yekaterina Polyatskaya; Alexis Donneys; Steven R Buchman Journal: J Craniofac Surg Date: 2019 Mar/Apr Impact factor: 1.046
Authors: R Rothweiler; S Kuhn; T Stark; S Heinemann; A Hoess; M A Fuessinger; L S Brandenburg; R Roelz; M C Metzger; U Hubbe Journal: J Mater Sci Mater Med Date: 2022-10-20 Impact factor: 4.727
Authors: Adam S DeConde; Matthew K Lee; Douglas Sidell; Tara Aghaloo; Min Lee; Sotirios Tetradis; Kyle Low; David Elashoff; Tristan Grogan; Ali R Sepahdari; Maie St John Journal: JAMA Otolaryngol Head Neck Surg Date: 2014-01 Impact factor: 6.223
Authors: Nattharee Chanchareonsook; Rüdiger Junker; Leenaporn Jongpaiboonkit; John A Jansen Journal: Tissue Eng Part B Rev Date: 2013-08-28 Impact factor: 6.389