Literature DB >> 19286131

Taming tuberculosis: a challenge for science and society.

Carl Nathan1.   

Abstract

Despite scientific advances, we are losing ground against Mycobacterium tuberculosis, a pathogen with which a third of us share our lives. Challenges include fundamental biologic questions; hurdles for translational medicine; and societal deficits in resources, incentives, collaboration, and leadership. Fortunately, the crisis is inspiring scientific and organizational creativity.

Entities:  

Mesh:

Substances:

Year:  2009        PMID: 19286131     DOI: 10.1016/j.chom.2009.02.004

Source DB:  PubMed          Journal:  Cell Host Microbe        ISSN: 1931-3128            Impact factor:   21.023


  21 in total

1.  A journey in science: promise, purpose, privilege.

Authors:  Carl Nathan
Journal:  Mol Med       Date:  2013-10-03       Impact factor: 6.354

2.  Minding the gaps: metabolomics mends functional genomics.

Authors:  Kyu Rhee
Journal:  EMBO Rep       Date:  2013-10-01       Impact factor: 8.807

Review 3.  Tuberculosis Drug Development: History and Evolution of the Mechanism-Based Paradigm.

Authors:  Sumit Chakraborty; Kyu Y Rhee
Journal:  Cold Spring Harb Perspect Med       Date:  2015-04-15       Impact factor: 6.915

4.  Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier.

Authors:  Kyu Y Rhee; Luiz Pedro Sorio de Carvalho; Ruslana Bryk; Sabine Ehrt; Joeli Marrero; Sae Woong Park; Dirk Schnappinger; Aditya Venugopal; Carl Nathan
Journal:  Trends Microbiol       Date:  2011-05-10       Impact factor: 17.079

Review 5.  Allostery and compartmentalization: old but not forgotten.

Authors:  Hyungjin Eoh; Kyu Y Rhee
Journal:  Curr Opin Microbiol       Date:  2014-03-05       Impact factor: 7.934

6.  Virulence of Mycobacterium tuberculosis depends on lipoamide dehydrogenase, a member of three multienzyme complexes.

Authors:  Aditya Venugopal; Ruslana Bryk; Shuangping Shi; Kyu Rhee; Poonam Rath; Dirk Schnappinger; Sabine Ehrt; Carl Nathan
Journal:  Cell Host Microbe       Date:  2011-01-20       Impact factor: 21.023

7.  Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials.

Authors:  Ben Gold; Maneesh Pingle; Steven J Brickner; Nilesh Shah; Julia Roberts; Mark Rundell; W Clay Bracken; Thulasi Warrier; Selin Somersan; Aditya Venugopal; Crystal Darby; Xiuju Jiang; J David Warren; Joseph Fernandez; Ouathek Ouerfelli; Eric L Nuermberger; Amy Cunningham-Bussel; Poonam Rath; Tamutenda Chidawanyika; Haiteng Deng; Ronald Realubit; J Fraser Glickman; Carl F Nathan
Journal:  Proc Natl Acad Sci U S A       Date:  2012-09-10       Impact factor: 11.205

8.  Rifamycin action on RNA polymerase in antibiotic-tolerant Mycobacterium tuberculosis results in differentially detectable populations.

Authors:  Kohta Saito; Thulasi Warrier; Selin Somersan-Karakaya; Lina Kaminski; Jianjie Mi; Xiuju Jiang; Suna Park; Kristi Shigyo; Ben Gold; Julia Roberts; Elaina Weber; William R Jacobs; Carl F Nathan
Journal:  Proc Natl Acad Sci U S A       Date:  2017-05-30       Impact factor: 11.205

9.  What can immunology contribute to the control of the world's leading cause of death from bacterial infection?

Authors:  Carl Nathan
Journal:  Immunol Rev       Date:  2015-03       Impact factor: 12.988

10.  Small-molecule inhibitors for the Prp8 intein as antifungal agents.

Authors:  Zhong Li; Anil Mathew Tharappel; Jimin Xu; Yuekun Lang; Cathleen M Green; Jing Zhang; Qishan Lin; Sudha Chaturvedi; Jia Zhou; Marlene Belfort; Hongmin Li
Journal:  Proc Natl Acad Sci U S A       Date:  2021-01-12       Impact factor: 11.205

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.