Literature DB >> 24089245

A journey in science: promise, purpose, privilege.

Carl Nathan1.   

Abstract

Real innovations in medicine and science are historic and singular; the stories behind each occurrence are precious. At Molecular Medicine we have established the Anthony Cerami Award in Translational Medicine to document and preserve these histories. The monographs recount the seminal events as told in the voice of the original investigators who provided the crucial early insight. These essays capture the essence of discovery, chronicling the birth of ideas that created new fields of research; and launched trajectories that persisted and ultimately influenced how disease is prevented, diagnosed, and treated. In this volume, the first Cerami Award Monograph, by Carl Nathan, MD, chairman of the Department of Microbiology and Immunology at Weill Cornell Medical College, reflects towering genius and soaring inspiration.

Mesh:

Year:  2013        PMID: 24089245      PMCID: PMC3789094          DOI: 10.2119/molmed.2013.00063

Source DB:  PubMed          Journal:  Mol Med        ISSN: 1076-1551            Impact factor:   6.354


  90 in total

1.  Treatment of visceral leishmaniasis with pentavalent antimony and interferon gamma.

Authors:  R Badaro; E Falcoff; F S Badaro; E M Carvalho; D Pedral-Sampaio; A Barral; J S Carvalho; M Barral-Netto; M Brandely; L Silva
Journal:  N Engl J Med       Date:  1990-01-04       Impact factor: 91.245

2.  Interferon-gamma-receptor deficiency in an infant with fatal bacille Calmette-Guérin infection.

Authors:  E Jouanguy; F Altare; S Lamhamedi; P Revy; J F Emile; M Newport; M Levin; S Blanche; E Seboun; A Fischer; J L Casanova
Journal:  N Engl J Med       Date:  1996-12-26       Impact factor: 91.245

3.  Gamma-interferon transcriptionally regulates an early-response gene containing homology to platelet proteins.

Authors:  A D Luster; J C Unkeless; J V Ravetch
Journal:  Nature       Date:  1985 Jun 20-26       Impact factor: 49.962

4.  Identification of nitric oxide synthase as a protective locus against tuberculosis.

Authors:  J D MacMicking; R J North; R LaCourse; J S Mudgett; S K Shah; C F Nathan
Journal:  Proc Natl Acad Sci U S A       Date:  1997-05-13       Impact factor: 11.205

5.  Production of large amounts of hydrogen peroxide by human tumor cells.

Authors:  T P Szatrowski; C F Nathan
Journal:  Cancer Res       Date:  1991-02-01       Impact factor: 12.701

6.  Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon-gamma and bacterial lipopolysaccharide.

Authors:  Q W Xie; C Nathan
Journal:  Trans Assoc Am Physicians       Date:  1993

7.  Inducible nitric oxide synthase requires both the canonical calmodulin-binding domain and additional sequences in order to bind calmodulin and produce nitric oxide in the absence of free Ca2+.

Authors:  J Ruan; Q w Xie; N Hutchinson; H Cho; G C Wolfe; C Nathan
Journal:  J Biol Chem       Date:  1996-09-13       Impact factor: 5.157

8.  Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase.

Authors:  J D MacMicking; C Nathan; G Hom; N Chartrain; D S Fletcher; M Trumbauer; K Stevens; Q W Xie; K Sokol; N Hutchinson
Journal:  Cell       Date:  1995-05-19       Impact factor: 41.582

9.  Role of activated macrophages in antibody-dependent lysis of tumor cells.

Authors:  C Nathan; L Brukner; G Kaplan; J Unkeless; Z Cohn
Journal:  J Exp Med       Date:  1980-07-01       Impact factor: 14.307

10.  Macrophage deactivation by interleukin 10.

Authors:  C Bogdan; Y Vodovotz; C Nathan
Journal:  J Exp Med       Date:  1991-12-01       Impact factor: 14.307

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  1 in total

Review 1.  Macrophage Heterogeneity in the Immunopathogenesis of Tuberculosis.

Authors:  Mohlopheni J Marakalala; Fernando O Martinez; Annette Plüddemann; Siamon Gordon
Journal:  Front Microbiol       Date:  2018-05-23       Impact factor: 5.640

  1 in total

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