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Literature DB >> 19279723

Wnt signaling in breast organogenesis.

Abstract

Wnt signals play a critical role in regulating the normal development of the mammary gland and dysregulation of Wnt signaling causes breast cancer. This pathway is involved in the earliest development of the mammary gland in embryos and its role extends through the functional differentiation of the gland during pregnancy. In this review, we summarize the molecular mechanisms through which Wnts regulate mammary gland development in the mouse.

Entities: Disease Species

Keywords: Wnt; cancer; embryo; mammary gland; postnatal; stem cell

Year: 2008 PMID： 19279723 PMCID： PMC2634257 DOI： 10.4161/org.4.2.5858

Source DB: PubMed Journal: Organogenesis ISSN： 1547-6278 Impact factor: 2.500

68 in total

1. Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex.

Authors: Thomas Kramps; Oliver Peter; Erich Brunner; Denise Nellen; Barbara Froesch; Sandipan Chatterjee; Maximilien Murone; Stephanie Züllig; Konrad Basler
Journal: Cell Date: 2002-04-05 Impact factor: 41.582

Review 2. A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling.

Authors: Michael T Veeman; Jeffrey D Axelrod; Randall T Moon
Journal: Dev Cell Date: 2003-09 Impact factor: 12.270

Review 3. Think globally, act locally: the making of a mouse mammary gland.

Authors: L Hennighausen; G W Robinson
Journal: Genes Dev Date: 1998-02-15 Impact factor: 11.361

4. Armadillo/beta-catenin signals in the nucleus--proof beyond a reasonable doubt?

Authors: Mariann Bienz; Hans Clevers
Journal: Nat Cell Biol Date: 2003-03 Impact factor: 28.824

5. Links between signal transduction, transcription and adhesion in epithelial bud development.

Authors: Colin Jamora; Ramanuj DasGupta; Pawel Kocieniewski; Elaine Fuchs
Journal: Nature Date: 2003-03-20 Impact factor: 49.962

6. Identification of c-MYC as a target of the APC pathway.

Authors: T C He; A B Sparks; C Rago; H Hermeking; L Zawel; L T da Costa; P J Morin; B Vogelstein; K W Kinzler
Journal: Science Date: 1998-09-04 Impact factor: 47.728

7. Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis.

Authors: Emily Y Chu; Julie Hens; Thomas Andl; Alladin Kairo; Terry P Yamaguchi; Cathrin Brisken; Adam Glick; John J Wysolmerski; Sarah E Millar
Journal: Development Date: 2004-09-01 Impact factor: 6.868

8. Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4.

Authors: V Korinek; N Barker; P Moerer; E van Donselaar; G Huls; P J Peters; H Clevers
Journal: Nat Genet Date: 1998-08 Impact factor: 38.330

9. The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway.

Authors: M Shtutman; J Zhurinsky; I Simcha; C Albanese; M D'Amico; R Pestell; A Ben-Ze'ev
Journal: Proc Natl Acad Sci U S A Date: 1999-05-11 Impact factor: 11.205

10. Pygopus, a nuclear PHD-finger protein required for Wingless signaling in Drosophila.

Authors: David S Parker; Jemileh Jemison; Kenneth M Cadigan
Journal: Development Date: 2002-06 Impact factor: 6.868

33 in total

Review 1. Wnt signaling in mammary glands: plastic cell fates and combinatorial signaling.

Authors: Caroline M Alexander; Shruti Goel; Saja A Fakhraldeen; Soyoung Kim
Journal: Cold Spring Harb Perspect Biol Date: 2012-10-01 Impact factor: 10.005

2. Regulation of breast cancer-induced bone lesions by β-catenin protein signaling.

Authors: Yan Chen; Heidi Y Shi; Stuart R Stock; Paula H Stern; Ming Zhang
Journal: J Biol Chem Date: 2011-10-18 Impact factor: 5.157

3. Tumor suppressor function of RUNX3 in breast cancer.

Authors: Lin-Feng Chen
Journal: J Cell Biochem Date: 2012-05 Impact factor: 4.429

Review 4. Oncogenic role and therapeutic target of leptin signaling in breast cancer and cancer stem cells.

Authors: Shanchun Guo; Mingli Liu; Guangdi Wang; Marta Torroella-Kouri; Ruben R Gonzalez-Perez
Journal: Biochim Biophys Acta Date: 2012-01-24

Review 5. microRNA regulation of Wnt signaling pathways in development and disease.

Authors: Jia L Song; Priya Nigam; Senel S Tektas; Erica Selva
Journal: Cell Signal Date: 2015-04-02 Impact factor: 4.315

6. MicroRNA-340 inhibits the migration, invasion, and metastasis of breast cancer cells by targeting Wnt pathway.

Authors: Samira Mohammadi-Yeganeh; Mahdi Paryan; Ehsan Arefian; Mohammad Vasei; Hossein Ghanbarian; Reza Mahdian; Morteza Karimipoor; Masoud Soleimani
Journal: Tumour Biol Date: 2016-01-12

7. Expression Patterns of the Wnt Pathway Inhibitors Dickkopf3 and Secreted Frizzled-Related Proteins 1 and 4 in Endometrial Endometrioid Adenocarcinoma: An NRG Oncology/Gynecologic Oncology Group Study.

Authors: Ramez N Eskander; Shamshad Ali; Thanh Dellinger; Heather A Lankes; Leslie M Randall; Nilsa C Ramirez; Bradley J Monk; Joan L Walker; Eric Eisenhauer; Bang H Hoang
Journal: Int J Gynecol Cancer Date: 2016-01 Impact factor: 3.437