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Literature DB >> 22275124

Tumor suppressor function of RUNX3 in breast cancer.

Abstract

Emerging evidence indicates that RUNX3 is a tumor suppressor in breast cancer. RUNX3 is frequently inactivated in human breast cancer cell lines and cancer samples by hemizygous deletion of the Runx3 gene, hypermethylation of the Runx3 promoter, or cytoplasmic sequestration of RUNX3 protein. Inactivation of RUNX3 is associated with the initiation and progression of breast cancer. Female Runx3(+/-) mice spontaneously develop ductal carcinoma, and overexpression of RUNX3 inhibits the proliferation, tumorigenic potential, and invasiveness of breast cancer cells. This review is intended to summarize these findings and discuss the tumor suppressor function of RUNX3 in breast cancer.

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Year: 2012 PMID： 22275124 PMCID： PMC3337355 DOI： 10.1002/jcb.24074

Source DB: PubMed Journal: J Cell Biochem ISSN： 0730-2312 Impact factor: 4.429

75 in total

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Authors: Suk-Chul Bae; Yong Hee Lee
Journal: Gene Date: 2005-12-01 Impact factor: 3.688

2. Wnt signaling in breast organogenesis.

Authors: Kata Boras-Granic; John J Wysolmerski
Journal: Organogenesis Date: 2008-04 Impact factor: 2.500

Review 3. Control of RUNX3 by histone methyltransferases.

Authors: You Mie Lee
Journal: J Cell Biochem Date: 2011-02 Impact factor: 4.429

4. Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation.

Authors: Yun-Hye Jin; Eun-Joo Jeon; Qing-Lin Li; Yong Hee Lee; Joong-Kook Choi; Wun-Jae Kim; Kwang-Youl Lee; Suk-Chul Bae
Journal: J Biol Chem Date: 2004-05-10 Impact factor: 5.157

5. Stromal gene expression predicts clinical outcome in breast cancer.

Authors: Greg Finak; Nicholas Bertos; Francois Pepin; Svetlana Sadekova; Margarita Souleimanova; Hong Zhao; Haiying Chen; Gulbeyaz Omeroglu; Sarkis Meterissian; Atilla Omeroglu; Michael Hallett; Morag Park
Journal: Nat Med Date: 2008-04-27 Impact factor: 53.440

6. Methylation of RUNX3 in various types of human cancers and premalignant stages of gastric carcinoma.

Authors: Tai Young Kim; Hyeon Joo Lee; Kyu Sang Hwang; Minjin Lee; Jae Won Kim; Yung-Jue Bang; Gyeong Hoon Kang
Journal: Lab Invest Date: 2004-04 Impact factor: 5.662

Review 7. Molecular pathology of RUNX3 in human carcinogenesis.

Authors: Manish Mani Subramaniam; Jason Yongsheng Chan; Khay Guan Yeoh; Timothy Quek; Kosei Ito; Manuel Salto-Tellez
Journal: Biochim Biophys Acta Date: 2009-08-12

8. The leukemic protein core binding factor beta (CBFbeta)-smooth-muscle myosin heavy chain sequesters CBFalpha2 into cytoskeletal filaments and aggregates.

Authors: N Adya; T Stacy; N A Speck; P P Liu
Journal: Mol Cell Biol Date: 1998-12 Impact factor: 4.272

9. Runt-related transcription factor RUNX3 is a target of MDM2-mediated ubiquitination.

Authors: Xin-Zi Chi; Jiyeon Kim; Yong-Hee Lee; Jung-Won Lee; Kyeong-Sook Lee; Heejun Wee; Wun-Jae Kim; Woo-Yoon Park; Byung-Chul Oh; Gary S Stein; Yoshiaki Ito; Andre J van Wijnen; Suk-Chul Bae
Journal: Cancer Res Date: 2009-10-06 Impact factor: 12.701

10. Enhancer of zeste homologue 2 (EZH2) down-regulates RUNX3 by increasing histone H3 methylation.

Authors: Satoshi Fujii; Kosei Ito; Yoshiaki Ito; Atsushi Ochiai
Journal: J Biol Chem Date: 2008-04-22 Impact factor: 5.157

31 in total

1. Investigation of methylation and protein expression of the Runx3 gene in colon carcinogenesis.

Authors: Shao-Ya He; Ren-Fa Jiang; Jie Jiang; Yang-Sheng Xiang; Ling Wang
Journal: Biomed Rep Date: 2015-06-17

2. Apoptotic effect of pheophorbide a-mediated photodynamic therapy on DMBA/TPA-induced mouse papillomas.

Authors: Xianglan Zhang; Eun Joo Choi; Zhenlong Zheng; Lianhua Zhu; Sung Bin Cho; Ki-Yoel Kim; Jin Kim; In-Ho Cha
Journal: Lasers Med Sci Date: 2014-06-21 Impact factor: 3.161

3. MicroRNA-93 inhibits apoptosis and promotes proliferation, invasion and migration of renal cell carcinoma ACHN cells via the TGF-β/Smad signaling pathway by targeting RUNX3.

Authors: Li-Jie Liu; Jian-Jun Yu; Xiao-Lin Xu
Journal: Am J Transl Res Date: 2017-07-15 Impact factor: 4.060

Review 4. Progress of Regenerative Therapy in Orthopedics.

Authors: Sunita Nayak; Geetha Manivasagam; Dwaipayan Sen
Journal: Curr Osteoporos Rep Date: 2018-04 Impact factor: 5.096

5. RUNX3 is a prognostic marker and potential therapeutic target in human breast cancer.

Authors: Jin Bai; Hong-Mei Yong; Fei-Fei Chen; Wen-Bo Song; Chen Li; Hui Liu; Jun-Nian Zheng
Journal: J Cancer Res Clin Oncol Date: 2013-09-04 Impact factor: 4.553

6. The roles of RUNX3 in cervical cancer cells in vitro.

Authors: Zhen Li; Pan Fan; Min Deng; Chao Zeng
Journal: Oncol Lett Date: 2018-04-04 Impact factor: 2.967

7. Placental DNA methylation alterations associated with maternal tobacco smoking at the RUNX3 gene are also associated with gestational age.

Authors: Jennifer Z J Maccani; Devin C Koestler; Eugene Andrés Houseman; Carmen J Marsit; Karl T Kelsey
Journal: Epigenomics Date: 2013-12 Impact factor: 4.778