Literature DB >> 12646868

Armadillo/beta-catenin signals in the nucleus--proof beyond a reasonable doubt?

Mariann Bienz1, Hans Clevers.   

Abstract

Wnt signalling results in transcriptional stimulation of genes controlling normal and malignant development. A key effector of the canonical Wnt pathway is beta-catenin (also known as Drosophila melanogaster Armadillo (Arm)), thought to function as a nuclear co-activator of TCF transcription factors. This has been challenged by unexpected observations of membrane-bound Arm/beta-catenin signalling activity. Plausible explanations allow these observations to be reconciled with the large body of evidence supporting a nuclear function of Arm/beta-catenin.

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Year:  2003        PMID： 12646868     DOI： 10.1038/ncb0303-179

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.824


  52 in total

Review 1.  Tumor viruses and cell signaling pathways: deubiquitination versus ubiquitination.

Authors:  Julia Shackelford; Joseph S Pagano
Journal:  Mol Cell Biol       Date:  2004-06       Impact factor: 4.272

2.  Canonical Wnt signaling is critical to estrogen-mediated uterine growth.

Authors:  Xiaonan Hou; Yi Tan; Meiling Li; Sudhansu K Dey; Sanjoy K Das
Journal:  Mol Endocrinol       Date:  2004-09-09

3.  Both LRP5 and LRP6 receptors are required to respond to physiological Wnt ligands in mammary epithelial cells and fibroblasts.

Authors:  Shruti Goel; Emily N Chin; Saja A Fakhraldeen; Scott M Berry; David J Beebe; Caroline M Alexander
Journal:  J Biol Chem       Date:  2012-03-20       Impact factor: 5.157

4.  Wnt-dependent regulation of inner ear morphogenesis is balanced by the opposing and supporting roles of Shh.

Authors:  Martin M Riccomagno; Shinji Takada; Douglas J Epstein
Journal:  Genes Dev       Date:  2005-06-16       Impact factor: 11.361

5.  Identification of DNA-dependent protein kinase catalytic subunit as a novel interaction partner of lymphocyte enhancer factor 1.

Authors:  Atsushi Shimomura; Akihiko Takasaki; Ryuji Nomura; Nobuhiro Hayashi; Takao Senda
Journal:  Med Mol Morphol       Date:  2013-01-17       Impact factor: 2.309

Review 6.  The role of estrogen and androgen receptors in bone health and disease.

Authors:  Stavros C Manolagas; Charles A O'Brien; Maria Almeida
Journal:  Nat Rev Endocrinol       Date:  2013-09-17       Impact factor: 43.330

7.  c-Jun N-terminal kinase 1 interacts with and negatively regulates Wnt/beta-catenin signaling through GSK3beta pathway.

Authors:  Dong Hu; Wenfeng Fang; Anjia Han; Lindsay Gallagher; Roger J Davis; Bin Xiong; Wancai Yang
Journal:  Carcinogenesis       Date:  2008-10-24       Impact factor: 4.944

8.  Defining the roles of beta-catenin and plakoglobin in LEF/T-cell factor-dependent transcription using beta-catenin/plakoglobin-null F9 cells.

Authors:  Masayuki Shimizu; Yoshitaka Fukunaga; Junichi Ikenouchi; Akira Nagafuchi
Journal:  Mol Cell Biol       Date:  2007-11-05       Impact factor: 4.272

9.  Estrogen receptor-α signaling in osteoblast progenitors stimulates cortical bone accrual.

Authors:  Maria Almeida; Srividhya Iyer; Marta Martin-Millan; Shoshana M Bartell; Li Han; Elena Ambrogini; Melda Onal; Jinhu Xiong; Robert S Weinstein; Robert L Jilka; Charles A O'Brien; Stavros C Manolagas
Journal:  J Clin Invest       Date:  2012-12-10       Impact factor: 14.808

10.  Cooperative control via lymphoid enhancer factor 1/T cell factor 3 and estrogen receptor-alpha for uterine gene regulation by estrogen.

Authors:  Sanhita Ray; Fuhua Xu; Haibin Wang; Sanjoy K Das
Journal:  Mol Endocrinol       Date:  2008-01-17
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