BACKGROUND: The impact of melanoma genetic testing and counseling on photoprotective behaviors is unknown. OBJECTIVE: To determine if genetic testing and counseling alter compliance with photoprotection recommendations. METHODS: Reported use of sunscreen, protective clothing, and sun avoidance by 59 members of CDKN2A/p16-mutation positive pedigrees was assessed as a function of mutation status and melanoma history, before, immediately after, and 1 month following test reporting. RESULTS: Intentions to practice all photoprotective behaviors increased in all participant groups (P < .0001). At 1 month, 33% of participants reported the adoption of a new photoprotective behavior. Subpopulation analyses identified different patterns of change in photoprotection relative to baseline (P < .005), with no net decline in any group. LIMITATIONS: This initial study of CDKN2A/p16 families is small and awaits replication in a larger sample. CONCLUSION: Melanoma genetic testing and counseling enhanced intentions to implement photoprotective strategies and did not result in reduced compliance in the CDKN2A/p16-subpopulation.
BACKGROUND: The impact of melanoma genetic testing and counseling on photoprotective behaviors is unknown. OBJECTIVE: To determine if genetic testing and counseling alter compliance with photoprotection recommendations. METHODS: Reported use of sunscreen, protective clothing, and sun avoidance by 59 members of CDKN2A/p16-mutation positive pedigrees was assessed as a function of mutation status and melanoma history, before, immediately after, and 1 month following test reporting. RESULTS: Intentions to practice all photoprotective behaviors increased in all participant groups (P < .0001). At 1 month, 33% of participants reported the adoption of a new photoprotective behavior. Subpopulation analyses identified different patterns of change in photoprotection relative to baseline (P < .005), with no net decline in any group. LIMITATIONS: This initial study of CDKN2A/p16 families is small and awaits replication in a larger sample. CONCLUSION:Melanoma genetic testing and counseling enhanced intentions to implement photoprotective strategies and did not result in reduced compliance in the CDKN2A/p16-subpopulation.
Authors: Yelena P Wu; Bridget G Parsons; Lisa G Aspinwall; Jennifer L Hay; Kenneth M Boucher; Heloisa Caputo; Ryan Mooney; Douglas Grossman; Sancy A Leachman Journal: Pediatr Dermatol Date: 2019-03-20 Impact factor: 1.588
Authors: Paolo A Ascierto; Antonio M Grimaldi; Ana Carrizosa Anderson; Carlo Bifulco; Alistair Cochran; Claus Garbe; Alexander M Eggermont; Mark Faries; Soldano Ferrone; Jeffrey E Gershenwald; Thomas F Gajewski; Ruth Halaban; F Stephen Hodi; Richard Kefford; John M Kirkwood; James Larkin; Sancy Leachman; Michele Maio; Richard Marais; Giuseppe Masucci; Ignacio Melero; Giuseppe Palmieri; Igor Puzanov; Antoni Ribas; Yvonne Saenger; Bastian Schilling; Barbara Seliger; David Stroncek; Ryan Sullivan; Alessandro Testori; Ena Wang; Gennaro Ciliberto; Nicola Mozzillo; Francesco M Marincola; Magdalena Thurin Journal: J Transl Med Date: 2014-10-28 Impact factor: 5.531
Authors: Lisa G Aspinwall; Jennifer M Taber; Samantha L Leaf; Wendy Kohlmann; Sancy A Leachman Journal: Cancer Epidemiol Biomarkers Prev Date: 2013-08-15 Impact factor: 4.254
Authors: Lisa G Aspinwall; Jennifer M Taber; Wendy Kohlmann; Samantha L Leaf; Sancy A Leachman Journal: J Genet Couns Date: 2013-12-10 Impact factor: 2.537
Authors: Yelena P Wu; Lisa G Aspinwall; Bridgid M Conn; Tammy Stump; Bridget Grahmann; Sancy A Leachman Journal: Prev Med Date: 2016-04-16 Impact factor: 4.018