Literature DB >> 19270699

Neonatal desensitization allows long-term survival of neural xenotransplants without immunosuppression.

Claire M Kelly1, Sophie V Precious, Caroline Scherf, Richard Penketh, Nazar N Amso, Alysia Battersby, Nicholas D Allen, Stephen B Dunnett, Anne E Rosser.   

Abstract

Preclinical development of human cells for potential therapeutic application in neurodegenerative diseases requires that their long-term survival, stability and functional efficacy be studied in animal models of human disease. Here we describe a strategy for long-term immune protection of human fetal and stem cell-derived neural cells transplanted into the adult rat brain, by desensitizing the host rat to similar cells in the neonatal period, without the need for additional immunosuppression.

Entities:  

Mesh：

Year:  2009        PMID： 19270699     DOI： 10.1038/nmeth.1308

Source DB:  PubMed          Journal:  Nat Methods        ISSN： 1548-7091            Impact factor:   28.547


  14 in total

1.  The potential for circuit reconstruction by expanded neural precursor cells explored through porcine xenografts in a rat model of Parkinson's disease.

Authors:  Richard J E Armstrong; Carrie B Hurelbrink; Pam Tyers; Emma L Ratcliffe; Andrew Richards; Stephen B Dunnett; Anne E Rosser; Roger A Barker
Journal:  Exp Neurol       Date:  2002-05       Impact factor: 5.330

2.  Phenotypic development of the human embryonic striatal primordium: a study of cultured and grafted neurons from the lateral and medial ganglionic eminences.

Authors:  E M Grasbon-Frodl; N Nakao; O Lindvall; P Brundin
Journal:  Neuroscience       Date:  1996-07       Impact factor: 3.590

Review 3.  Improving the survival of grafted dopaminergic neurons: a review over current approaches.

Authors:  P Brundin; J Karlsson; M Emgård; G S Schierle; O Hansson; A Petersén; R F Castilho
Journal:  Cell Transplant       Date:  2000 Mar-Apr       Impact factor: 4.064

4.  Human fetal mesencephalic tissue grafted to dopamine-denervated striatum of athymic rats: light- and electron-microscopical histochemistry and in vivo chronoamperometric studies.

Authors:  I Strömberg; P Almqvist; M Bygdeman; T E Finger; G Gerhardt; A C Granholm; T J Mahalik; A Seiger; L Olson; B Hoffer
Journal:  J Neurosci       Date:  1989-02       Impact factor: 6.167

5.  Transplantation of human striatal tissue into a rodent model of Huntington's disease: phenotypic expression of transplanted neurons and host-to-graft innervation.

Authors:  L L Pundt; T Kondoh; J A Conrad; W C Low
Journal:  Brain Res Bull       Date:  1996       Impact factor: 4.077

6.  Neural xenotransplantation: reconstruction of neuronal circuitry across species barriers.

Authors:  P Pakzaban; O Isacson
Journal:  Neuroscience       Date:  1994-10       Impact factor: 3.590

7.  Prevention of mouse-rat brain xenograft rejection by a combination therapy of cyclosporin A, prednisolone and azathioprine.

Authors:  E B Pedersen; F R Poulsen; J Zimmer; B Finsen
Journal:  Exp Brain Res       Date:  1995       Impact factor: 1.972

8.  Human fetal dopamine neurons grafted in a rat model of Parkinson's disease: immunological aspects, spontaneous and drug-induced behaviour, and dopamine release.

Authors:  P Brundin; R E Strecker; H Widner; D J Clarke; O G Nilsson; B Astedt; O Lindvall; A Björklund
Journal:  Exp Brain Res       Date:  1988       Impact factor: 1.972

9.  Long-term effects of human-to-rat mesencephalic xenografts on rotational behavior, striatal dopamine receptor binding, and mRNA levels.

Authors:  I Strömberg; C Adams; M Bygdeman; B Hoffer; S Boyson; C Humpel
Journal:  Brain Res Bull       Date:  1995       Impact factor: 4.077

10.  A scaleable and defined system for generating neural stem cells from human embryonic stem cells.

Authors:  Alexis J Joannides; Christelle Fiore-Hériché; Alysia A Battersby; Pandula Athauda-Arachchi; Isabelle A Bouhon; Lydia Williams; Kristine Westmore; Paul J Kemp; Alastair Compston; Nicholas D Allen; Siddharthan Chandran
Journal:  Stem Cells       Date:  2006-11-09       Impact factor: 6.277
View more
  18 in total

Review 1.  Concise Review: Human-Animal Neurological Chimeras: Humanized Animals or Human Cells in an Animal?

Authors:  Andrew T Crane; Joseph P Voth; Francis X Shen; Walter C Low
Journal:  Stem Cells       Date:  2019-01-28       Impact factor: 6.277

Review 2.  Potential barriers to therapeutics utilizing pluripotent cell derivatives: intrinsic immunogenicity of in vitro maintained and matured populations.

Authors:  Chad Tang; Micha Drukker
Journal:  Semin Immunopathol       Date:  2011-04-11       Impact factor: 9.623

3.  Neonatal immune-tolerance in mice does not prevent xenograft rejection.

Authors:  Virginia B Mattis; Dustin R Wakeman; Colton Tom; Hemraj B Dodiya; Sylvia Y Yeung; Andrew H Tran; Ksenija Bernau; Loren Ornelas; Anais Sahabian; Jack Reidling; Dhruv Sareen; Leslie M Thompson; Jeffrey H Kordower; Clive N Svendsen
Journal:  Exp Neurol       Date:  2014-01-16       Impact factor: 5.330

4.  Neonatal desensitization does not universally prevent xenograft rejection.

Authors:  Miroslaw Janowski; Anna Jablonska; Hanna Kozlowska; Inema Orukari; Segun Bernard; Jeff W M Bulte; Barbara Lukomska; Piotr Walczak
Journal:  Nat Methods       Date:  2012-09       Impact factor: 28.547

5.  Efficient derivation of NPCs, spinal motor neurons and midbrain dopaminergic neurons from hESCs at 3% oxygen.

Authors:  S R L Stacpoole; B Bilican; D J Webber; A Luzhynskaya; X L He; A Compston; R Karadottir; R J M Franklin; S Chandran
Journal:  Nat Protoc       Date:  2011-07-28       Impact factor: 13.491

6.  Neonatal desensitization supports long-term survival and functional integration of human embryonic stem cell-derived mesenchymal stem cells in rat joint cartilage without immunosuppression.

Authors:  Shufang Zhang; Yang Zi Jiang; Wei Zhang; Longkun Chen; Tong Tong; Wanlu Liu; Qin Mu; Hua Liu; Junfeng Ji; Hong Wei Ouyang; Xiaohui Zou
Journal:  Stem Cells Dev       Date:  2012-08-14       Impact factor: 3.272

7.  Experimental study of vein subvolution combined with neural stem cells to repair sciatic neurologic defects in rats.

Authors:  Kang Li; Yan Jiang; Dianming Jiang
Journal:  Int J Clin Exp Pathol       Date:  2015-09-01

8.  Spontaneous Graft-Induced Dyskinesias Are Independent of 5-HT Neurons and Levodopa Priming in a Model of Parkinson's Disease.

Authors:  Emma L Lane; David J Harrison; Elena Ramos-Varas; Rachel Hills; Sophie Turner; Mariah J Lelos
Journal:  Mov Disord       Date:  2021-11-12       Impact factor: 9.698

9.  Human Müller glia with stem cell characteristics differentiate into retinal ganglion cell (RGC) precursors in vitro and partially restore RGC function in vivo following transplantation.

Authors:  Shweta Singhal; Bhairavi Bhatia; Hari Jayaram; Silke Becker; Megan F Jones; Phillippa B Cottrill; Peng T Khaw; Thomas E Salt; G Astrid Limb
Journal:  Stem Cells Transl Med       Date:  2012-03-07       Impact factor: 6.940

10.  Transplantation of photoreceptors derived from human Muller glia restore rod function in the P23H rat.

Authors:  Hari Jayaram; Megan F Jones; Karen Eastlake; Phillippa B Cottrill; Silke Becker; Joseph Wiseman; Peng T Khaw; G Astrid Limb
Journal:  Stem Cells Transl Med       Date:  2014-01-29       Impact factor: 6.940
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.