Tomoaki Shiba1, Yukihiro Sato, Mao Takahashi. 1. Department of Ophthalmology, Toho University Sakura Medical Center, Sakura, Chiba, Japan. tomoaki-s@sakura.med.toho-u.ac.jp
Abstract
PURPOSE: To clarify the relationships of sleep-disordered breathing (SDB) to nonproliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR). DESIGN: Cross sectional case-control study. METHODS: Forty-eight consecutive NPDR and 118 PDR cases that had undergone surgery in our hospital were included in this study. Pulse oximetry was conducted during the night and the sleeping 4% oxygen desaturation index (ODI) (number of oxygen desaturation events/hour exceeding 4%) and mean SpO(2)% were calculated. If 4% ODI > 5 times/hour, SDB was diagnosed. The results were evaluated and compared between the 2 groups. In addition, these results and preoperative patient background factors were analyzed using multiple regression analysis to identify correlations with the diagnosis of PDR. RESULTS: Twenty-nine percent of the NPDR and 48% of the PDR patients were diagnosed as having SDB. The incidence of SDB and the 4% ODI/hour value were significantly higher in the PDR than in the NPDR group (P = .003 and .03, respectively). Multiple regression analysis showed younger age and a higher 4% ODI value to be factors independently contributing to a diagnosis of PDR (age, standard regression coefficient = -0.34; t value = -4.44; P < .0001; 4% ODI, standard regression coefficient = 0.20; t value = 2.15; P = .03, correlation coefficient (R) = 0.43). CONCLUSION: Our results suggest that, in diabetic retinopathy patients with nocturnal desaturation, reoxygenation caused by SDB may relate to the development of PDR.
PURPOSE: To clarify the relationships of sleep-disordered breathing (SDB) to nonproliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR). DESIGN: Cross sectional case-control study. METHODS: Forty-eight consecutive NPDR and 118 PDR cases that had undergone surgery in our hospital were included in this study. Pulse oximetry was conducted during the night and the sleeping 4% oxygen desaturation index (ODI) (number of oxygen desaturation events/hour exceeding 4%) and mean SpO(2)% were calculated. If 4% ODI > 5 times/hour, SDB was diagnosed. The results were evaluated and compared between the 2 groups. In addition, these results and preoperative patient background factors were analyzed using multiple regression analysis to identify correlations with the diagnosis of PDR. RESULTS: Twenty-nine percent of the NPDR and 48% of the PDR patients were diagnosed as having SDB. The incidence of SDB and the 4% ODI/hour value were significantly higher in the PDR than in the NPDR group (P = .003 and .03, respectively). Multiple regression analysis showed younger age and a higher 4% ODI value to be factors independently contributing to a diagnosis of PDR (age, standard regression coefficient = -0.34; t value = -4.44; P < .0001; 4% ODI, standard regression coefficient = 0.20; t value = 2.15; P = .03, correlation coefficient (R) = 0.43). CONCLUSION: Our results suggest that, in diabetic retinopathypatients with nocturnal desaturation, reoxygenation caused by SDB may relate to the development of PDR.
Authors: Azizi Seixas; Alberto R Ramos; Georgiana M Gordon-Strachan; Vilma Aparecida da Silva Fonseca; Ferdinand Zizi; Girardin Jean-Louis Journal: J Sleep Med Disord Date: 2014
Authors: James Patrick Smith; Luke G Cyr; Laura K Dowd; Kyla S Duchin; Priscilla A Lenihan; Jennifer Sprague Journal: Optom Vis Sci Date: 2019-11 Impact factor: 1.973